You asked about Therapeutics
91 people built something like it. 9 are gone.
That is 10% of the ones whose fate we could settle, against 23% across the whole register. 5 were acquired.
| Launched | What it was | Today |
|---|---|---|
| 2020-01-01 | A nonprofit stool bank enabling access to fecal transplants. · openbiome.org | still up |
| 2019-06-01 | Discovering the true signals of disease to power life-changing drugs. · sequencebio.com | still up |
| 2020-01-01 | RNA medicines for liver diseases · ochre-bio.com | still up |
| 2019-06-01 | Building AI therapeutics for physical health conditions like IBS. · mindsethealth.com | still up |
| 2018-01-01 | Engineering next-generation, brain-penetrant cancer therapies. · reverielabs.com | gone |
| 2021-06-01 | Unlocking the next generation of mRNA medicines · sensible.bio | still up |
| 2019-01-01 | Precision-first therapies · endpointhealth.com | gone |
| 2021-06-01 | YCInflow A self-help app for people to manage their ADHD. · getinflow.io | acquired |
| 2020-06-01 | Kernal is creating mRNA 2.0 therapies that work in specific cells · kernalbio.com | still up |
| 2019-01-01 | YC1910 Multimodal AI Platform for Modality Agnostic Drug Discovery™ · 1910.ai | still up |
| 2018-06-01 | Fermentation-derived natural products to solve health problems · cbthera.com | still up |
| 2021-06-01 | Diversifying precision cancer diagnostics and treatments · yemaachi.com | still up |
| 2020-01-01 | Using CRISPR to find treatments for cancer and inflammation · algenbio.com | still up |
| 2019-01-01 | We solve drug resistance for cancer · resistance.bio | gone |
| 2021-01-01 | Discovering bispecific antibody drug-conjugates (BsADC) against cancer · valinktx.com | still up |
| 2020-06-01 | Gilgamesh Pharmaceuticals, a Clinical stage biotechnology company… · gilgameshpharmaceutical.com | still up |
| 2020-01-01 | We create activating antibodies to treat diseases others can’t. · abalonebio.com | still up |
| 2018-01-01 | Computational antibody design · macromoltek.com | still up |
| 2017-06-01 | We bank your stem cells to help you live healthier, longer. · foreverlabs.com | still up |
| 2021-01-01 | YCPipeBio PipeBio is a SaaS bioinformatics platform to develop antibody drugs. · pipebio.com | acquired |
| 2022-01-01 | Potent, durable, and redosable non-viral genetic medicines · engagebio.com | acquired |
| 2025-01-01 | AI drug discovery platform for neurotherapeutics · exintherapeutics.com | still up |
| 2021-06-01 | YCSafeBeat Guiding cardiac therapeutics - all from your phone · safebeat.com | still up |
| 2018-06-01 | New therapeutics to rejuvenate tissue and treat age-related diseases · doriantherapeutics.com | acquired |
| 2021-06-01 | Multi-targeted therapeutics to treat complex diseases · harmonicdiscovery.com | still up |
| 2021-01-01 | YCBiodock Cloud AI microscopy automation · biodock.ai | still up |
| 2024-01-01 | Building programmable therapeutics for the immune system · granzabio.com | still up |
| 2021-06-01 | Using protein coupling to build new therapies · catenabiosciences.com | still up |
| 2023-01-01 | Adventris makes cancer vaccines · adventris.com | still up |
| 2018-01-01 | We are using the gut microbiome to end cancer. · persephonebiosciences.com | still up |
| 2023-01-01 | Developing long-lasting drug formulations 50% faster · persist-ai.com | still up |
| 2018-06-01 | Developing novel therapeutics for aging and chronic disease · gerostatealpha.com | gone |
| 2025-06-01 | RNA intelligence for precision medicine · blank.bio | still up |
| 2020-01-01 | Altay develops disease-modifying therapies targeting transcription… · altaytherapeutics.com | still up |
| 2020-01-01 | We’re creating programmable therapies · felixbt.com | gone |
| 2018-06-01 | Utilizing monogenic disorders to inform and solve highly complex… · circumventpharmaceuticals.com | still up |
| 2024-01-01 | Elevated mRNA for transformative medicines. · parcelbio.com | still up |
| 2022-06-01 | Combinations therapy by rational design · serinus.bio | still up |
| 2022-01-01 | High-precision, closed-loop neuromodulation devices · torpedotherapeutics.com | still up |
| 2023-06-01 | Combination therapeutics for the world's toughest diseases · oliolabs.co | still up |
| 2026-06-01 | Full Stack Pharmaceutical Company for Personalized Peptides and GLP-1s · ronanrx.com | still up |
| 2018-01-01 | YCNectome Human whole body end-of-life preservation for later revival. · nectome.com | still up |
| 2024-01-01 | Breakthrough medicines unlocking the biology of heme · velorumtx.com | still up |
| 2020-06-01 | Curative genetic medicines for kidney diseases · nephrogenbiotech.com | still up |
| 2023-06-01 | YCNanograb Deliver genes to any cell with AI · nanograb.com | still up |
| 2021-01-01 | Genetic Medicine with Small Molecules · serna.bio | still up |
| 2022-06-01 | Platform injectable gel based therapeutic for osteoarthritis · relevium-medical.com | still up |
| 2021-06-01 | A platform to make artificial viruses as cancer therapeutics. · humanegenomics.com | still up |
| 2018-06-01 | YCHepatx Replacing organ transplant with an infusion · hepatx.com | still up |
| 2026-01-01 | YCOrigin AI and Data for Cancer Therapeutics · origin.bio | still up |
| 2022-01-01 | Oral drugs to halt neurodegeneration · origamitherapeutics.com | still up |
| 2021-06-01 | Regulating the immune system to block cancer & autoimmune diseases · sfatherapeutics.com | still up |
| 2021-06-01 | Developing milk-inspired therapeutics for infectious diseases · matrubials.com | still up |
| 2019-01-01 | Smart gels for local drug delivery to the gut · intacttherapeutics.com | still up |
| 2019-01-01 | Living therapies for pets first, and their people next · leahlabs.com | still up |
| 2018-06-01 | YCdNovo The cure for hair loss. · dnovobio.com | gone |
| 2023-01-01 | We teach your immune system to attack and cure cancer · modularit.bio | still up |
| 2022-01-01 | Empowering Mass Spec for Biotech and Beyond · andsonbiotech.com | still up |
| 2019-06-01 | EncepHeal develops medications to treat substance abuse, starting… · encepheal.com | gone |
| 2026-06-01 | YCWonderTx Extrapolative AI to unlock First-in-Class drugs · wondertx.ai | still up |
How this compares
The register re-probes every domain it holds. Some that answered last month stop answering. We send that list — what went quiet, and what it was — once a month. Nothing else.
How this was made. Show HN entries are every post from 2021 to 2023 with at least five points that linked to its own domain; code hosts and free hosting are excluded, because a repository outlives the effort behind it. Product Hunt entries needed 100 votes — a far higher bar, so they are the promoted top slice rather than a like-for-like sample. Both are judged by asking the domain whether it still answers: gone means it no longer resolves, refuses the connection, serves a parking page, or says plainly that it shut down. An HTTP error is not counted as gone — a server answering 404 is one somebody still pays for, and an audit of 25 gone-calls found two such sites alive with only a moved homepage. Y Combinator entries use the status YC publishes itself, which is why only those can say acquired. Squatted domains — a lapsed name now serving somebody else's site — are not detected, so these figures run slightly low.