You asked about Genetic Engineering
98 people built something like it. 13 are gone.
That is 16% of the ones whose fate we could settle, against 23% across the whole register. 16 were acquired.
| Launched | What it was | Today |
|---|---|---|
| 2023-06-01 | Genetically engineering plants for disease resistance. · ohmicbiosciences.com | still up |
| 2023-08-07 | chainforge.ai | still up |
| 2023-05-09 | engineeringbookclub.com | still up |
| 2023-04-02 | prompt-engineering-jobs.com | moved |
| 2023-01-01 | YCResend Email for developers · resend.com | still up |
| 2023-01-01 | YCPirros AI Platform for Architects and Engineers · pirros.com | still up |
| 2023-06-01 | YCGiga AI Support Agent for Enterprises. · giga.ai | still up |
| 2023-01-01 | YCFern Instantly offer SDKs and API Docs · buildwithfern.com | acquired |
| 2023-01-01 | YCClueso Create beautiful videos & docs for any product or process in minutes · clueso.io | still up |
| 2023-01-01 | YCVellum vellum.ai | still up |
| 2023-01-01 | YCDepot Software delivery built for machine scale. · depot.dev | still up |
| 2023-01-01 | YCLangfuse Open source LLM engineering platform · langfuse.com | acquired |
| 2023-06-01 | YCTiptap The open-source document editor for humans and AI agents. · tiptap.dev | still up |
| 2023-06-01 | YCNumen Engineering a future without cancer deaths. · numen.com | still up |
| 2023-01-01 | YCInkeep Build AI Agent teammates and automations in code or no-code · inkeep.com | still up |
| 2023-04-02 | uimakers.club | gone |
| 2023-01-29 | dystr.com | still up |
| 2023-06-01 | YCArtie Software that streams data from databases to warehouses in real-time · artie.com | still up |
| 2023-01-23 | docs.phidata.com | still up |
| 2023-01-01 | YCVersori Agentic integrations & automations for enterprise · versori.com | acquired |
| 2023-05-03 | datawithrust.com | still up |
| 2023-06-01 | The GPU Cloud Marketplace · shadeform.ai | still up |
| 2023-01-01 | Go from idea to production with AI. · magicpatterns.com | still up |
| 2023-06-01 | YCrefine Open-source Retool for enterprise · refine.dev | still up |
| 2023-01-01 | YCPierre Pierre is a new, opinionated, git platform. · pierre.co | still up |
| 2023-06-01 | AI for Government Contracting. · sweetspot.so | still up |
| 2023-01-01 | YCIcePanel Design and explain complex software architecture. · icepanel.io | still up |
| 2023-06-24 | middlewarehq.com | still up |
| 2023-01-01 | Build and deploy fully‑managed AI agents and workflows · trigger.dev | still up |
| 2023-01-01 | Phone AI that Captures Every Dealership Revenue Opportunity · shortloop.dev | still up |
| 2023-01-01 | The open source, fullstack monitoring platform: stop guessing why… · highlight.io | acquired |
| 2023-01-01 | YCDrDroid Your best friend in production. · drdroid.io | still up |
| 2023-06-01 | YCTempo Visual Editor for React, powered by AI · tempo.new | still up |
| 2023-06-01 | YCSilimate Fast, efficient agents for chip design and debug · silimate.com | still up |
| 2023-11-14 | product.distoai.com | unverified |
| 2023-03-15 | learnprompting.org | still up |
| 2023-01-01 | YCSkyhook PaaS-like experience with the power of Kubernetes, on your cloud · skyhook.io | still up |
| 2023-01-01 | YCRelace Models and infra for coding agents · relace.ai | still up |
| 2023-03-21 | devscreen.io | gone |
| 2023-06-01 | YCSID AI research center for retrieval · sid.ai | still up |
| 2023-06-01 | YCSpine AI Manage a swarm of AI agents to get real work done · getspine.ai | still up |
| 2023-01-01 | YCFastgen Webflow for the Backend · fastgen.com | still up |
| 2023-01-01 | YCHoneydew The home for shared data logic · honeydew.ai | still up |
| 2023-01-01 | YCOhm Ohm helps engineering teams accelerate hardware development & testing. · ohm.ai | still up |
| 2023-06-01 | YCCedalio AI agents that automate AP, procurement, and finance · cedalio.com | still up |
| 2023-01-01 | YCNango A single API for all your integrations · nango.dev | still up |
| 2023-06-01 | Open source GenAI development platform · flowiseai.com | acquired |
| 2023-03-22 | bemi.ai | moved |
| 2023-06-01 | AI for ASIC Design Verification · bronco.ai | still up |
| 2023-01-01 | AI agents for end-to-end testing · trynarrative.com | still up |
| 2023-01-01 | YCKeep The open-source AIOps platform · keephq.dev | acquired |
| 2023-07-25 | ai-porn-generator.co | unverified |
| 2023-01-01 | AI-powered game translation. · magnaplay.com | still up |
| 2023-01-12 | handcalc.com | gone |
| 2023-06-01 | Farm Genetics Made Easy - Using DNA and Software · feanixbio.com | still up |
| 2023-06-01 | The publishing layer for the agentic internet · structuredlabs.com | gone |
| 2023-01-01 | YCLynx AI platform for investigating and resolving engineering incidents · uselynx.ai | gone |
| 2023-01-01 | YCLume Speed up customer implementation with AI · lume.ai | acquired |
| 2023-06-01 | YCSweep The best AI coding assistant for JetBrains · sweep.dev | still up |
| 2023-06-01 | Aide is an AI-native , privacy-first IDE built on top of VSCode · aide.dev | gone |
How this compares
Y Combinator reports its own outcomes, including acquisitions. The other two are judged by asking the domain, so they are not measured the same way and are never averaged together.
The register re-probes every domain it holds. Some that answered last month stop answering. We send that list — what went quiet, and what it was — once a month. Nothing else.
How this was made. Show HN entries are every post from 2021 to 2023 with at least five points that linked to its own domain; code hosts and free hosting are excluded, because a repository outlives the effort behind it. Product Hunt entries needed 100 votes — a far higher bar, so they are the promoted top slice rather than a like-for-like sample. Both are judged by asking the domain whether it still answers: gone means it no longer resolves, refuses the connection, serves a parking page, or says plainly that it shut down. An HTTP error is not counted as gone — a server answering 404 is one somebody still pays for, and an audit of 25 gone-calls found two such sites alive with only a moved homepage. Y Combinator entries use the status YC publishes itself, which is why only those can say acquired. Squatted domains — a lapsed name now serving somebody else's site — are not detected, so these figures run slightly low.