You asked about Genetic Engineering
72 people built something like it. 10 are gone.
That is 17% of the ones whose fate we could settle, against 23% across the whole register. 12 were acquired.
| Launched | What it was | Today |
|---|---|---|
| 2022-10-20 | playerzero.app | unverified |
| 2022-03-16 | devcycle.com | still up |
| 2022-01-01 | AI-native operating system for home service businesses · broccoli.com | still up |
| 2022-01-01 | YCMintlify The intelligent knowledge platform · mintlify.com | still up |
| 2022-12-14 | devblogs.co | still up |
| 2022-01-01 | Compliant-Ready AI for the Enterprise · dynamo.ai | still up |
| 2022-01-01 | YCBotCity Observability and Governance for AI-Generated Python scripts. · botcity.dev | still up |
| 2022-01-01 | YCLanceDB Open-source, serverless vectordb for production-scale generative AI · lancedb.com | still up |
| 2022-01-01 | YCRally Agentic User Research Infrastructure · rallyuxr.com | still up |
| 2022-01-01 | YCSieve The multimodal data lab · sievedata.com | still up |
| 2022-06-01 | Engineering the future of chemistry for natural resource extraction · maverickx.com | still up |
| 2022-01-01 | YCHomeRoom We Rent Your Property by the Room. You earn 50% more Rent. · livehomeroom.com | acquired |
| 2022-01-01 | YCTheneo Stripe-like API Docs in just a few clicks · theneo.io | still up |
| 2022-01-01 | YCCUTR The marketplace for wood manufacturing · cutr.ai | still up |
| 2022-12-11 | learnprompting.org | still up |
| 2022-01-01 | Open-Source Postman alternative · requestly.com | acquired |
| 2022-06-21 | scenario.tech | gone |
| 2022-01-01 | Automated QA for your Digital Analytics · trackingplan.com | still up |
| 2022-01-01 | YCSarus Use personal data for analytics and ML, safely and seamlessly · sarus.tech | acquired |
| 2022-06-01 | YCIntuned Code-first scrapers and RPAs — built and maintained by AI · intunedhq.com | still up |
| 2022-06-01 | A scalable, cloud-native Perforce and Git alternative · diversion.dev | still up |
| 2022-01-01 | Software to launch and integrate genetics into clinical care · nestgenomics.com | still up |
| 2022-01-16 | techengineering.io | still up |
| 2022-01-01 | Open-source data observability for data teams · elementary-data.com | still up |
| 2022-12-14 | goodtechthings.com | still up |
| 2022-06-01 | YCLamin Open data platform for traceable, multimodal AI · lamin.ai | still up |
| 2022-01-01 | Potent, durable, and redosable non-viral genetic medicines · engagebio.com | acquired |
| 2022-01-01 | AI-driven HVAC control system for improved energy performance · axross.co | still up |
| 2022-06-01 | Open-source, AI-first and no-code business automation tool · activepieces.com | still up |
| 2022-01-01 | YCVimmerse Bring your photos to life with Vimmerse · vimmerse.net | still up |
| 2022-08-18 | tryeraser.com | moved |
| 2022-01-01 | Visually design and manage cloud infrastructures. · brainboard.co | still up |
| 2022-01-01 | YCConvoy Webhooks Gateway for outgoing and incoming webhooks. · getconvoy.io | still up |
| 2022-01-01 | Automating all IT operations · stackshine.com | acquired |
| 2022-01-01 | YCPloomber Heroku for AI · ploomber.io | gone |
| 2022-01-01 | No-Code LLM Application / Workflow Builder · queryvary.com | still up |
| 2022-06-01 | YCNuMind Create custom NLP models · numind.ai | still up |
| 2022-06-01 | Turn user feedback to product insights · monterey.ai | acquired |
| 2022-01-01 | YCHydra Serverless Analytics on Postgres · hydra.so | acquired |
| 2022-01-01 | Run compute-intensive apps in a browser · jamsocket.com | acquired |
| 2022-08-31 | devscreen.io | gone |
| 2022-06-01 | AI for modern automotive dealerships · useclearline.com | still up |
| 2022-01-01 | Team-based authentication for B2B SaaS · propelauth.com | still up |
| 2022-06-01 | YCSanifu Automate the repetitive work spreadsheets are used for · sanifu.ai | still up |
| 2022-01-01 | YCPelm Plaid for utilities · pelm.com | gone |
| 2022-01-01 | YCVessel Developer-first, native integration platform for GTM tools · vessel.dev | gone |
| 2022-01-01 | Internal developer platform for Terraform, OpenTofu and Helm · massdriver.cloud | still up |
| 2022-01-01 | YCNyckel Classify Anything · nyckel.com | still up |
| 2022-01-01 | We make Orca, MIT open source terminal-based agent orchestrator · onorca.dev | still up |
| 2022-01-01 | AI agents rewriting & optimising your internal documentation for LLMs · refinetrain.ai | still up |
| 2022-06-01 | YCRaven AI Assistants for Manufacturing Operations · startraven.com | still up |
| 2022-06-01 | YCInstant The best backend for AI-coded apps · instantdb.com | acquired |
| 2022-06-01 | YCStackup Stackup helps businesses manage their crypto assets. · stackup.fi | still up |
| 2022-06-01 | YCChordio Claude Code design workspace built for product teams · chordio.com | still up |
| 2022-06-01 | YCHyperDX Open-source, dev-friendly observability. · hyperdx.io | acquired |
| 2022-06-01 | Realtime Data Connectors · movinglake.com | still up |
| 2022-06-01 | YCSunpia Deploy serverless without rewriting code · sunpia.io | still up |
| 2022-06-01 | YCPayload Developer-First Headless CMS and Application Framework · payloadcms.com | acquired |
| 2022-01-01 | API for shared embeddable web browsers · hyperbeam.com | still up |
| 2022-06-01 | YCGrai Open source version control for metadata · grai.io | gone |
How this compares
Y Combinator reports its own outcomes, including acquisitions. The other two are judged by asking the domain, so they are not measured the same way and are never averaged together.
The register re-probes every domain it holds. Some that answered last month stop answering. We send that list — what went quiet, and what it was — once a month. Nothing else.
How this was made. Show HN entries are every post from 2021 to 2023 with at least five points that linked to its own domain; code hosts and free hosting are excluded, because a repository outlives the effort behind it. Product Hunt entries needed 100 votes — a far higher bar, so they are the promoted top slice rather than a like-for-like sample. Both are judged by asking the domain whether it still answers: gone means it no longer resolves, refuses the connection, serves a parking page, or says plainly that it shut down. An HTTP error is not counted as gone — a server answering 404 is one somebody still pays for, and an audit of 25 gone-calls found two such sites alive with only a moved homepage. Y Combinator entries use the status YC publishes itself, which is why only those can say acquired. Squatted domains — a lapsed name now serving somebody else's site — are not detected, so these figures run slightly low.