You asked about Gene Therapy
72 people built something like it. 6 are gone.
That is 9% of the ones whose fate we could settle, against 23% across the whole register. 3 were acquired.
| Launched | What it was | Today |
|---|---|---|
| 2024-01-01 | Elevated mRNA for transformative medicines. · parcelbio.com | still up |
| 2024-06-01 | Genetically engineered viruses that teach your immune system to kill… · kopra.bio | still up |
| 2024-01-01 | YCLegora The AI workspace for lawyers · legora.com | still up |
| 2024-09-01 | AI tutors for students. · generallearning.com | still up |
| 2024-01-01 | YCOpen Enterprise AI customer support · open.cx | still up |
| 2024-06-01 | YCHenry Automating Deal Decks for Commercial Real Estate Brokers · henry.ai | still up |
| 2024-06-01 | YCSaturn Compliance and back office workflows for Wealth Managers. · saturnos.com | still up |
| 2024-06-01 | Automate security and privacy reviews · clearly-ai.com | still up |
| 2024-01-01 | Building The Next Generation of Night Vision Devices · deepnight.com | still up |
| 2024-06-01 | YCUsul AI Platform for Winning Defense & Government Contracts · usul.com | still up |
| 2024-06-01 | YCMem0 The Memory layer for AI Agents · mem0.ai | still up |
| 2024-01-01 | YCROE AI for risk and compliance · getroe.ai | still up |
| 2024-06-01 | YCArgil The video generation engine for the creator economy · argil.ai | still up |
| 2024-01-01 | YCSenso Control what AI says about you · senso.ai | still up |
| 2024-06-01 | Open-Source Reinforcement Learning (RL) & Fine-tuning for LLMs. · unsloth.ai | still up |
| 2024-06-01 | YCKenley AI Agents for Advisory & Financial Services. · kenley.ai | still up |
| 2024-06-01 | YCDataleap AI Employees for the Enterprise · dataleap.ai | still up |
| 2024-06-01 | We're training the next generation of protein foundation models. · anthrogen.com | still up |
| 2024-06-01 | YCVoker The Agent Analytics Platform · voker.ai | still up |
| 2024-01-01 | Autonomously scaling environments · vibrantlabs.com | still up |
| 2024-06-01 | AI Report Generation for Engineering & Environmental Review · schemeflow.com | still up |
| 2024-01-01 | YCMarblism AI Employees who love overtime · marblism.com | still up |
| 2024-01-01 | YCInteguru Generate fast, reliable APIs for any platform · integuru.com | still up |
| 2024-01-01 | Making it easy for B2B sales teams to send stellar outbound · meticulate.ai | still up |
| 2024-01-01 | YCMathos Ultimate AI Math Problem Solver to Revolutionize Personalized Learning · info.mathos.ai | still up |
| 2024-09-01 | YCx1 AI app builder for creating and launching iPhone apps · x1.new | still up |
| 2024-01-01 | YCShepherd Every student's personalized learning assistant · shepherd.study | still up |
| 2024-06-01 | YCScape The intelligent inbox that works for you · scape.app | still up |
| 2024-06-01 | YCcamfer Building the world’s first AI mechanical engineer. · camfer.dev | gone |
| 2024-06-01 | YCUltra Practical, general-purpose robots for repetitive industrial tasks · ultra.tech | still up |
| 2024-06-01 | YCRemade AI-native canvas for creative workflows. · remade.ai | acquired |
| 2024-06-01 | The Open Source Agentic Browser · browseros.com | still up |
| 2024-01-01 | YCDuckie Build AI Support Agents in Minutes · duckie.ai | still up |
| 2024-06-01 | YCACX Next-generation biocides for sustainable agriculture at scale · acxtherapeutics.com | still up |
| 2024-01-01 | An all-in-one platform for building internal agents & workflows · keystroke.ai | still up |
| 2024-01-01 | YCTusk AI agent that generates unit and integration tests · usetusk.ai | acquired |
| 2024-01-01 | The AI Labor Company · brainbaselabs.com | still up |
| 2024-06-01 | YCMagiCode A Reliable AI Frontend Engineer · magicode.ai | still up |
| 2024-06-01 | YCRentFlow The AI infrastructure for cash-flow-aligned business rent · therentflow.com | still up |
| 2024-06-01 | Java-native multi-agentic AI operating system for enterprise · redouble.ai | still up |
| 2024-06-01 | Making Next-Generation Antibiotics that Outpace Bacterial Evolution · evolverebiosciences.com | still up |
| 2024-06-01 | YCInvaria The next generation logging and observability platform · invaria.com | gone |
| 2024-01-01 | Connecting All Ages with Speech Language Pathologists · versetherapy.com | acquired |
| 2024-09-01 | Scaling Genomic AI for Embryo Selection · reticular.com | still up |
| 2024-01-01 | YCPenciled AI front office assistant for physical therapy · penciled.com | still up |
| 2024-01-01 | AI media creation platform for creators and developers · magichour.ai | still up |
| 2024-01-01 | YCAdapted AI physical therapy for athletes · adapted.app | still up |
| 2024-01-01 | GenAI Interactive story. Creator write fictions 10x faster. · storioai.com | still up |
| 2024-01-01 | YCAedilic Open-Source AI-generated image/deepfake detection · nonescape.com | gone |
| 2024-01-01 | YCOneGrep AI Agent for DevOps Workflow Automation · onegrep.dev | still up |
| 2024-01-01 | AI Therapy for OCD · themangohealth.com | gone |
| 2024-06-01 | YCKura AI New State of the Art for Browser Agents · trykura.com | still up |
| 2024-06-01 | YCLore Transform your iMessage conversations into shareable stories · joinlore.app | still up |
| 2024-06-01 | ideate.xyz is an AI-powered 3D art suite on the web · ideate.xyz | still up |
| 2024-09-01 | YCEndstack The complete, collaborative workspace for humans and agents · endstack.com | still up |
| 2024-06-01 | YCDreamRP Tech and platforms for human creators and the entertainment industry · dreamrp.com | still up |
| 2024-06-01 | YCTypa The content engine that wins attention and drives growth. · typa.ai | still up |
| 2024-06-01 | YCPinnacle API & SDK for RCS (the next-generation of texting) · pinnacle.sh | still up |
| 2024-06-01 | YCDayflow Generate a detailed log of everything you've worked on, automatically. · dayflow.so | still up |
| 2024-01-01 | YCAbel Transforming document review for litigation teams · tryabel.com | gone |
How this compares
The register re-probes every domain it holds. Some that answered last month stop answering. We send that list — what went quiet, and what it was — once a month. Nothing else.
How this was made. Show HN entries are every post from 2021 to 2023 with at least five points that linked to its own domain; code hosts and free hosting are excluded, because a repository outlives the effort behind it. Product Hunt entries needed 100 votes — a far higher bar, so they are the promoted top slice rather than a like-for-like sample. Both are judged by asking the domain whether it still answers: gone means it no longer resolves, refuses the connection, serves a parking page, or says plainly that it shut down. An HTTP error is not counted as gone — a server answering 404 is one somebody still pays for, and an audit of 25 gone-calls found two such sites alive with only a moved homepage. Y Combinator entries use the status YC publishes itself, which is why only those can say acquired. Squatted domains — a lapsed name now serving somebody else's site — are not detected, so these figures run slightly low.