You asked about Gene Therapy
662 people built something like it. 115 are gone.
That is 18% of the ones whose fate we could settle, against 23% across the whole register. 39 were acquired.
| Launched | What it was | Today |
|---|---|---|
| 2022-01-01 | Unleashing the potential of DNA and RNA based therapies using AI · whitelabgx.com | still up |
| 2018-01-01 | Delivering RNA therapies. · sixfold.bio | still up |
| 2018-06-01 | YC64x Bio Enabling next generation medicines. A comprehensive platform and… · 64xbio.com | still up |
| 2024-01-01 | Elevated mRNA for transformative medicines. · parcelbio.com | still up |
| 2017-01-01 | Enabling T cell immunotherapy discovery, development and manufacturing · indeelabs.com | still up |
| 2020-06-01 | Curative genetic medicines for kidney diseases · nephrogenbiotech.com | still up |
| 2022-01-01 | Empowering Mass Spec for Biotech and Beyond · andsonbiotech.com | still up |
| 2023-01-01 | We teach your immune system to attack and cure cancer · modularit.bio | still up |
| 2021-01-01 | Cell-specific genetic medicines · nuntiustx.com | still up |
| 2024-06-01 | Genetically engineered viruses that teach your immune system to kill… · kopra.bio | still up |
| 2018-06-01 | mRNA therapeutics to extend healthspan entering clinical trials · rejuvenationtech.com | still up |
| 2018-06-01 | Democratizing gene therapy by reinventing its manufacturing and… · perception.bio | gone |
| 2025-01-01 | A Disease Focused Biotech, Building Multiple Billion Dollar Drugs · uncommontherapeutics.com | still up |
| 2022-05-04 | folk.app | still up |
| 2022-11-02 | photoai.com | still up |
| 2022-08-23 | pornpen.ai | gone |
| 2022-06-01 | equals.app | moved |
| 2022-06-20 | makerbox.club | still up |
| 2022-01-31 | hagrid.io | moved |
| 2022-11-30 | thegist.ai | gone |
| 2022-05-26 | freepodcastwebsites.com | moved |
| 2023-10-10 | eliot.blog | still up |
| 2018-06-01 | YCLeena AI We at Leena AI build a virtual assistant that answers employee's… · leena.ai | still up |
| 2022-05-05 | supermeme.ai | still up |
| 2021-09-19 | libgen.fun | unverified |
| 2022-10-19 | minicoursegenerator.com | still up |
| 2022-01-10 | meshgradient.in | still up |
| 2022-10-17 | designmodo.com | still up |
| 2022-04-18 | elai.io | still up |
| 2024-01-01 | YCLegora The AI workspace for lawyers · legora.com | still up |
| 2022-10-20 | durable.com | still up |
| 2022-02-07 | appmaster.io | still up |
| 2013-01-01 | YCHeap Captures user interactions with no code to generate analytics. · heap.io | acquired |
| 2022-07-31 | deck.rocks | unverified |
| 2022-05-03 | 1password.com | still up |
| 2022-10-24 | getitout.io | still up |
| 2022-06-15 | tango.us | moved |
| 2022-05-24 | doodooc.com | still up |
| 2022-10-11 | flatlogic.com | still up |
| 2022-04-13 | unrealengine.com | unverified |
| 2022-11-18 | questoapp.com | unverified |
| 2022-10-27 | snipd.com | still up |
| 2022-02-16 | uicolors.app | still up |
| 2022-10-27 | astria.ai | still up |
| 2017-06-01 | The genetic testing platform detecting and measuring disease. · billiontoone.com | acquired |
| 2022-07-19 | flowful.app | still up |
| 2023-03-28 | regex.ai | still up |
| 2022-02-15 | uigenerator.org | still up |
| 2023-02-21 | phind.com | unverified |
| 2022-06-01 | linkgraph.io | moved |
| 2022-05-08 | 11ty.dev | still up |
| 2022-04-19 | emacs.amodernist.com | gone |
| 2022-01-01 | YCHumand All-in-one app for internal communication and HR · humand.co | still up |
| 2022-10-07 | links.paradym.app | unverified |
| 2022-06-08 | reply.io | unverified |
| 2022-01-05 | nft-inator.com | still up |
| 2021-11-28 | tanck.nl | still up |
| 2023-04-26 | renewables-map.robinhawkes.com | still up |
| 2022-02-12 | lofigenerator.com | still up |
| 2023-03-22 | pyvibe.com | still up |
How this compares
Y Combinator reports its own outcomes, including acquisitions. The other two are judged by asking the domain, so they are not measured the same way and are never averaged together.
Older launches have had longer to die, so this slope is expected. A year that broke it would mean something is wrong with the checking.
The register re-probes every domain it holds. Some that answered last month stop answering. We send that list — what went quiet, and what it was — once a month. Nothing else.
How this was made. Show HN entries are every post from 2021 to 2023 with at least five points that linked to its own domain; code hosts and free hosting are excluded, because a repository outlives the effort behind it. Product Hunt entries needed 100 votes — a far higher bar, so they are the promoted top slice rather than a like-for-like sample. Both are judged by asking the domain whether it still answers: gone means it no longer resolves, refuses the connection, serves a parking page, or says plainly that it shut down. An HTTP error is not counted as gone — a server answering 404 is one somebody still pays for, and an audit of 25 gone-calls found two such sites alive with only a moved homepage. Y Combinator entries use the status YC publishes itself, which is why only those can say acquired. Squatted domains — a lapsed name now serving somebody else's site — are not detected, so these figures run slightly low.