You asked about Gene Therapy
384 people built something like it. 49 are gone.
That is 14% of the ones whose fate we could settle, against 23% across the whole register. 39 were acquired.
| Launched | What it was | Today |
|---|---|---|
| 2022-01-01 | Unleashing the potential of DNA and RNA based therapies using AI · whitelabgx.com | still up |
| 2018-01-01 | Delivering RNA therapies. · sixfold.bio | still up |
| 2018-06-01 | YC64x Bio Enabling next generation medicines. A comprehensive platform and… · 64xbio.com | still up |
| 2024-01-01 | Elevated mRNA for transformative medicines. · parcelbio.com | still up |
| 2020-06-01 | Curative genetic medicines for kidney diseases · nephrogenbiotech.com | still up |
| 2017-01-01 | Enabling T cell immunotherapy discovery, development and manufacturing · indeelabs.com | still up |
| 2023-01-01 | We teach your immune system to attack and cure cancer · modularit.bio | still up |
| 2022-01-01 | Empowering Mass Spec for Biotech and Beyond · andsonbiotech.com | still up |
| 2025-01-01 | A Disease Focused Biotech, Building Multiple Billion Dollar Drugs · uncommontherapeutics.com | still up |
| 2021-01-01 | Cell-specific genetic medicines · nuntiustx.com | still up |
| 2024-06-01 | Genetically engineered viruses that teach your immune system to kill… · kopra.bio | still up |
| 2018-06-01 | Democratizing gene therapy by reinventing its manufacturing and… · perception.bio | gone |
| 2018-06-01 | mRNA therapeutics to extend healthspan entering clinical trials · rejuvenationtech.com | still up |
| 2018-06-01 | YCLeena AI We at Leena AI build a virtual assistant that answers employee's… · leena.ai | still up |
| 2024-01-01 | YCLegora The AI workspace for lawyers · legora.com | still up |
| 2013-01-01 | YCHeap Captures user interactions with no code to generate analytics. · heap.io | acquired |
| 2017-06-01 | The genetic testing platform detecting and measuring disease. · billiontoone.com | acquired |
| 2022-01-01 | YCHumand All-in-one app for internal communication and HR · humand.co | still up |
| 2018-01-01 | Jasper is a leader in creating content using Artificial Intelligence · jasper.ai | still up |
| 2014-01-01 | YCAxoni Axoni is building the next generation of capital markets technology · axoni.com | acquired |
| 2020-06-01 | AI to engage employees, predict attrition and automate HR/IT support · infeedo.ai | still up |
| 2021-01-01 | YCPibit.ai The fastest path from submission to better decisions. · pibit.ai | still up |
| 2020-06-01 | We deliver personalized medicine for neurodegenerative patients · synapticure.com | still up |
| 2020-06-01 | Power commerce photography with generative AI · photoroom.com | still up |
| 2021-01-01 | Building the next generation AI creative studio · moonvalley.com | still up |
| 2021-06-01 | YCTavus Building the human layer of AI · tavus.io | still up |
| 2020-01-01 | Next-generation DNA synthesis using enzymes · ansabio.com | still up |
| 2022-06-01 | YCJuicebox AI-powered talent sourcing for recruiters · juicebox.ai | still up |
| 2022-01-01 | YCGovDash AI platform to win and run government contracts · govdash.com | still up |
| 2019-01-01 | YCLanded Generative AI for frontline worker hiring · gotlanded.com | still up |
| 2011-06-01 | LeadGenius is an account-based marketing and lead generation… · leadgenius.com | still up |
| 2020-06-01 | Contract and negotiation AI built for lawyers · draftwise.com | still up |
| 2019-01-01 | YC54Gene Precision medicine for Africans and the global population · 54gene.com | gone |
| 2023-06-01 | YCVetRec AI Scribe for veterinarians. Saving time and improving patient care. · vetrec.io | still up |
| 2017-06-01 | Sunfolding builds next generation infrastructure for solar farms. By… · sunfolding.com | gone |
| 2015-01-01 | Next generation infectious disease test kits · lucirahealth.com | acquired |
| 2023-01-01 | YCSalient AI Servicing for Auto Lenders · trysalient.com | still up |
| 2018-01-01 | Orangewood Labs makes worlds most affordable and easiest AI robot arms · orangewood.co | still up |
| 2023-01-01 | YCPlayAI Our mission is to make Voice AI accessible and useful to all. · play.ai | acquired |
| 2021-06-01 | Track & Boost Your Brand’s Visibility in AI Search · writesonic.com | still up |
| 2024-09-01 | AI tutors for students. · generallearning.com | still up |
| 2022-01-01 | YCBotCity Observability and Governance for AI-Generated Python scripts. · botcity.dev | still up |
| 2022-01-01 | YCLanceDB Open-source, serverless vectordb for production-scale generative AI · lancedb.com | still up |
| 2020-01-01 | Makes guilt-free plastics from food waste · genecis.co | still up |
| 2015-06-01 | Revenue generation for live events · ticketfairy.com | still up |
| 2018-01-01 | Making Anime Real · spellbrush.com | still up |
| 2022-01-01 | Virtualizing brick-mortar infrastructures of clinics w/ generative AI · ankr.us | still up |
| 2014-01-01 | YCMixerBox AI Super-Apps to Live Easier | The anything anytime superapps… · mixerbox.com | still up |
| 2023-01-01 | YCTruewind AI-Powered Accounting · truewind.ai | still up |
| 2023-06-01 | AI Operating System for Private Market Investors · vectorshift.ai | still up |
| 2021-01-01 | DreamWorld is a next-gen Minecraft with generative AI building · playdreamworld.com | still up |
| 2018-01-01 | Engineering next-generation, brain-penetrant cancer therapies. · reverielabs.com | gone |
| 2022-06-01 | Healthcare data infrastructure for next generation care delivery. · metriport.com | still up |
| 2021-01-01 | Generative AI powered Shopify for home service professionals · toplinepro.com | still up |
| 2016-06-01 | Bringing 3rd generation, nanopore sequencing to healthcare to solve… · shieldbio.com | gone |
| 2021-06-01 | The most magical personal Voice-Led AI English Learning Buddy for Kids · sparkstudio.co | still up |
| 2017-06-01 | YCD-ID Enable creators and developers to generate realistic AI personas · d-id.com | still up |
| 2026-01-01 | Elite AI law firm for high growth companies · general.legal | still up |
| 2023-01-01 | YCClueso Create beautiful videos & docs for any product or process in minutes · clueso.io | still up |
| 2018-01-01 | YCNaborly A credit bureau for the renting generation. · naborly.com | acquired |
How this compares
Older launches have had longer to die, so this slope is expected. A year that broke it would mean something is wrong with the checking.
The register re-probes every domain it holds. Some that answered last month stop answering. We send that list — what went quiet, and what it was — once a month. Nothing else.
How this was made. Show HN entries are every post from 2021 to 2023 with at least five points that linked to its own domain; code hosts and free hosting are excluded, because a repository outlives the effort behind it. Product Hunt entries needed 100 votes — a far higher bar, so they are the promoted top slice rather than a like-for-like sample. Both are judged by asking the domain whether it still answers: gone means it no longer resolves, refuses the connection, serves a parking page, or says plainly that it shut down. An HTTP error is not counted as gone — a server answering 404 is one somebody still pays for, and an audit of 25 gone-calls found two such sites alive with only a moved homepage. Y Combinator entries use the status YC publishes itself, which is why only those can say acquired. Squatted domains — a lapsed name now serving somebody else's site — are not detected, so these figures run slightly low.