You asked about Drug discovery
13 people built something like it. 5 are gone.
That is 38% of the ones whose fate we could settle, against 23% across the whole register.
| Launched | What it was | Today |
|---|---|---|
| 2023-01-01 | Generative AI for protein design · diffuse.bio | still up |
| 2023-01-01 | Adventris makes cancer vaccines · adventris.com | still up |
| 2023-01-01 | YCMiracle Accelerate clinical trials with real-time, actionable insights · miracleml.com | still up |
| 2023-01-01 | Developing long-lasting drug formulations 50% faster · persist-ai.com | still up |
| 2023-01-01 | YCInvitris Creating new protein-based drugs at scale · invitris.com | still up |
| 2023-01-01 | Empowering every doctor and every patient to participate in research · novel.care | still up |
| 2023-06-01 | YCNanograb Deliver genes to any cell with AI · nanograb.com | still up |
| 2023-06-01 | Combination therapeutics for the world's toughest diseases · oliolabs.co | still up |
| 2023-01-01 | AI for drug formulation · lavo.ai | gone |
| 2023-09-25 | octomind.dev | gone |
| 2023-03-08 | about.imma.app | gone |
| 2023-03-15 | styrate.co | gone |
| 2023-01-01 | AI Powered Product Discovery · rubberduckylabs.io | gone |
How this compares
Y Combinator reports its own outcomes, including acquisitions. The other two are judged by asking the domain, so they are not measured the same way and are never averaged together.
The register re-probes every domain it holds. Some that answered last month stop answering. We send that list — what went quiet, and what it was — once a month. Nothing else.
How this was made. Show HN entries are every post from 2021 to 2023 with at least five points that linked to its own domain; code hosts and free hosting are excluded, because a repository outlives the effort behind it. Product Hunt entries needed 100 votes — a far higher bar, so they are the promoted top slice rather than a like-for-like sample. Both are judged by asking the domain whether it still answers: gone means it no longer resolves, refuses the connection, serves a parking page, or says plainly that it shut down. An HTTP error is not counted as gone — a server answering 404 is one somebody still pays for, and an audit of 25 gone-calls found two such sites alive with only a moved homepage. Y Combinator entries use the status YC publishes itself, which is why only those can say acquired. Squatted domains — a lapsed name now serving somebody else's site — are not detected, so these figures run slightly low.