You asked about Drug discovery
130 people built something like it. 16 are gone.
That is 13% of the ones whose fate we could settle, against 23% across the whole register. 8 were acquired.
| Launched | What it was | Today |
|---|---|---|
| 2015-01-01 | Artificial intelligence for drug discovery. · numerionlabs.ai | still up |
| 2019-06-01 | Discovering the true signals of disease to power life-changing drugs. · sequencebio.com | still up |
| 2015-06-01 | We use human data and AI to develop better drugs faster. · vergegenomics.com | still up |
| 2015-01-01 | Personalized drug discovery for blood cancer. · notablelabs.com | acquired |
| 2022-01-01 | Unleashing the potential of DNA and RNA based therapies using AI · whitelabgx.com | still up |
| 2020-01-01 | YCPostEra Medicinal Chemistry powered by Machine Learning · postera.ai | still up |
| 2016-01-01 | YCQvin Empowering women. Period. · qvin.com | still up |
| 2018-01-01 | Engineering next-generation, brain-penetrant cancer therapies. · reverielabs.com | gone |
| 2018-01-01 | Delivering RNA therapies. · sixfold.bio | still up |
| 2021-06-01 | YCAdaptyv We're building fully automated labs for protein engineering · adaptyvbio.com | still up |
| 2017-01-01 | Next-generation mRNA platform to solve cancer, COVID and climate. · helixnano.com | still up |
| 2019-06-01 | Arpeggio Bio develops drugs targeting transcription factors using AI… · arpeggiobio.com | still up |
| 2021-06-01 | Using the immune system to cure disease · parallel.bio | still up |
| 2019-01-01 | YC1910 Multimodal AI Platform for Modality Agnostic Drug Discovery™ · 1910.ai | still up |
| 2024-01-01 | AI Inference Platform for Drug Discovery · tamarind.bio | still up |
| 2020-06-01 | Combining 3D cell culture & AI to translate drugs to clinical success · knownmed.com | acquired |
| 2021-06-01 | Discovering drugs that target the DNA regulome · talus.bio | still up |
| 2020-01-01 | The next generation of induced-proximity medicines. · generalproximity.bio | still up |
| 2019-01-01 | We solve drug resistance for cancer · resistance.bio | gone |
| 2021-01-01 | Discovering bispecific antibody drug-conjugates (BsADC) against cancer · valinktx.com | still up |
| 2020-01-01 | Using CRISPR to find treatments for cancer and inflammation · algenbio.com | still up |
| 2020-06-01 | Gilgamesh Pharmaceuticals, a Clinical stage biotechnology company… · gilgameshpharmaceutical.com | still up |
| 2018-01-01 | Computational antibody design · macromoltek.com | still up |
| 2020-01-01 | We create activating antibodies to treat diseases others can’t. · abalonebio.com | still up |
| 2017-06-01 | YCOncobox Finding the right cancer drug for each patient. · oncobox.com | still up |
| 2010-06-01 | YCTeevox Teevox · teevox.com | gone |
| 2022-01-01 | Potent, durable, and redosable non-viral genetic medicines · engagebio.com | acquired |
| 2023-01-01 | Generative AI for protein design · diffuse.bio | still up |
| 2021-01-01 | YCPipeBio PipeBio is a SaaS bioinformatics platform to develop antibody drugs. · pipebio.com | acquired |
| 2025-01-01 | AI drug discovery platform for neurotherapeutics · exintherapeutics.com | still up |
| 2021-06-01 | We make injections as easy as pushing a button! · pirouettepharma.com | still up |
| 2018-01-01 | Skin patches for generic drug delivery. · avrolifesci.com | still up |
| 2020-06-01 | We use AI to design antibodies for intractable diseases · nabla.bio | still up |
| 2021-06-01 | The foundation for the next era of biology · outputbio.com | still up |
| 2021-06-01 | Multi-targeted therapeutics to treat complex diseases · harmonicdiscovery.com | still up |
| 2023-01-01 | YCMiracle Accelerate clinical trials with real-time, actionable insights · miracleml.com | still up |
| 2021-06-01 | Programmable biology company for psychoactive effect design · mindstate.design | still up |
| 2023-01-01 | Adventris makes cancer vaccines · adventris.com | still up |
| 2020-01-01 | We’re creating programmable therapies · felixbt.com | gone |
| 2020-01-01 | Altay develops disease-modifying therapies targeting transcription… · altaytherapeutics.com | still up |
| 2018-01-01 | We are using the gut microbiome to end cancer. · persephonebiosciences.com | still up |
| 2023-01-01 | Developing long-lasting drug formulations 50% faster · persist-ai.com | still up |
| 2024-01-01 | Elevated mRNA for transformative medicines. · parcelbio.com | still up |
| 2023-01-01 | YCInvitris Creating new protein-based drugs at scale · invitris.com | still up |
| 2018-06-01 | New clinical tests for managing autoimmune treatments. · coralgenomics.com | acquired |
| 2024-06-01 | Gen AI molecular simulations that reproduce wetlab results · angstrom-ai.com | still up |
| 2023-06-01 | Combination therapeutics for the world's toughest diseases · oliolabs.co | still up |
| 2017-01-01 | Enabling T cell immunotherapy discovery, development and manufacturing · indeelabs.com | still up |
| 2022-06-01 | Platform injectable gel based therapeutic for osteoarthritis · relevium-medical.com | still up |
| 2023-01-01 | Empowering every doctor and every patient to participate in research · novel.care | still up |
| 2021-01-01 | Genetic Medicine with Small Molecules · serna.bio | still up |
| 2021-01-01 | Discover drugs that control how much cells "squeeze" to treat disease · forcytebio.com | gone |
| 2023-06-01 | YCNanograb Deliver genes to any cell with AI · nanograb.com | still up |
| 2024-01-01 | Breakthrough medicines unlocking the biology of heme · velorumtx.com | still up |
| 2019-06-01 | YCShiru Shiru leverages ML to create proteins to feed the world sustainably. · shiru.com | still up |
| 2024-06-01 | YCACX Next-generation biocides for sustainable agriculture at scale · acxtherapeutics.com | still up |
| 2022-01-01 | Oral drugs to halt neurodegeneration · origamitherapeutics.com | still up |
| 2022-06-01 | YCQuinn Your biopharma team, from molecule design to portfolio strategy · quinnbio.com | still up |
| 2019-01-01 | Living therapies for pets first, and their people next · leahlabs.com | still up |
| 2016-06-01 | YCSynvivia Synvivia applies chemical control over cell behavior · synvivia.com | still up |
How this compares
Y Combinator reports its own outcomes, including acquisitions. The other two are judged by asking the domain, so they are not measured the same way and are never averaged together.
The register re-probes every domain it holds. Some that answered last month stop answering. We send that list — what went quiet, and what it was — once a month. Nothing else.
How this was made. Show HN entries are every post from 2021 to 2023 with at least five points that linked to its own domain; code hosts and free hosting are excluded, because a repository outlives the effort behind it. Product Hunt entries needed 100 votes — a far higher bar, so they are the promoted top slice rather than a like-for-like sample. Both are judged by asking the domain whether it still answers: gone means it no longer resolves, refuses the connection, serves a parking page, or says plainly that it shut down. An HTTP error is not counted as gone — a server answering 404 is one somebody still pays for, and an audit of 25 gone-calls found two such sites alive with only a moved homepage. Y Combinator entries use the status YC publishes itself, which is why only those can say acquired. Squatted domains — a lapsed name now serving somebody else's site — are not detected, so these figures run slightly low.