You asked about Drug Delivery
193 people built something like it. 33 are gone.
That is 20% of the ones whose fate we could settle, against 23% across the whole register. 26 were acquired.
| Launched | What it was | Today |
|---|---|---|
| 2015-01-01 | Artificial intelligence for drug discovery. · numerionlabs.ai | still up |
| 2019-06-01 | Discovering the true signals of disease to power life-changing drugs. · sequencebio.com | still up |
| 2015-06-01 | We use human data and AI to develop better drugs faster. · vergegenomics.com | still up |
| 2022-01-01 | Unleashing the potential of DNA and RNA based therapies using AI · whitelabgx.com | still up |
| 2020-01-01 | YCPostEra Medicinal Chemistry powered by Machine Learning · postera.ai | still up |
| 2018-01-01 | Delivering RNA therapies. · sixfold.bio | still up |
| 2021-06-01 | YCAdaptyv We're building fully automated labs for protein engineering · adaptyvbio.com | still up |
| 2017-01-01 | Next-generation mRNA platform to solve cancer, COVID and climate. · helixnano.com | still up |
| 2019-06-01 | Arpeggio Bio develops drugs targeting transcription factors using AI… · arpeggiobio.com | still up |
| 2021-06-01 | Using the immune system to cure disease · parallel.bio | still up |
| 2021-06-01 | Discovering drugs that target the DNA regulome · talus.bio | still up |
| 2020-01-01 | The next generation of induced-proximity medicines. · generalproximity.bio | still up |
| 2020-01-01 | Using CRISPR to find treatments for cancer and inflammation · algenbio.com | still up |
| 2020-06-01 | Gilgamesh Pharmaceuticals, a Clinical stage biotechnology company… · gilgameshpharmaceutical.com | still up |
| 2020-01-01 | We create activating antibodies to treat diseases others can’t. · abalonebio.com | still up |
| 2018-01-01 | Computational antibody design · macromoltek.com | still up |
| 2023-01-01 | Generative AI for protein design · diffuse.bio | still up |
| 2021-06-01 | We make injections as easy as pushing a button! · pirouettepharma.com | still up |
| 2018-01-01 | Skin patches for generic drug delivery. · avrolifesci.com | still up |
| 2020-06-01 | We use AI to design antibodies for intractable diseases · nabla.bio | still up |
| 2021-06-01 | Multi-targeted therapeutics to treat complex diseases · harmonicdiscovery.com | still up |
| 2021-06-01 | The foundation for the next era of biology · outputbio.com | still up |
| 2023-01-01 | YCMiracle Accelerate clinical trials with real-time, actionable insights · miracleml.com | still up |
| 2021-06-01 | Programmable biology company for psychoactive effect design · mindstate.design | still up |
| 2023-01-01 | Adventris makes cancer vaccines · adventris.com | still up |
| 2020-01-01 | We’re creating programmable therapies · felixbt.com | gone |
| 2023-01-01 | Developing long-lasting drug formulations 50% faster · persist-ai.com | still up |
| 2023-01-01 | YCInvitris Creating new protein-based drugs at scale · invitris.com | still up |
| 2023-06-01 | Combination therapeutics for the world's toughest diseases · oliolabs.co | still up |
| 2023-01-01 | Empowering every doctor and every patient to participate in research · novel.care | still up |
| 2024-06-01 | Gen AI molecular simulations that reproduce wetlab results · angstrom-ai.com | still up |
| 2018-06-01 | New clinical tests for managing autoimmune treatments. · coralgenomics.com | acquired |
| 2017-01-01 | Enabling T cell immunotherapy discovery, development and manufacturing · indeelabs.com | still up |
| 2023-06-01 | YCNanograb Deliver genes to any cell with AI · nanograb.com | still up |
| 2022-06-01 | YCQuinn Your biopharma team, from molecule design to portfolio strategy · quinnbio.com | still up |
| 2021-06-01 | Developing milk-inspired therapeutics for infectious diseases · matrubials.com | still up |
| 2019-01-01 | Smart gels for local drug delivery to the gut · intacttherapeutics.com | still up |
| 2025-06-01 | YCConvexia The world's first AI-maximalist pharma company · convexia.bio | still up |
| 2021-06-01 | The dynamic single-cell analysis company · cellchorus.com | still up |
| 2026-01-01 | YCOrigin AI and Data for Cancer Therapeutics · origin.bio | still up |
| 2022-01-01 | Growing micro-organs to find new drugs · rosebudbiosciences.com | still up |
| 2026-01-01 | Evolutionary intelligence for autoimmune disease · dittobio.com | still up |
| 2023-01-01 | AI for drug formulation · lavo.ai | gone |
| 2025-09-01 | YCExonic Exonic is an AI-native cell and gene therapeutics company. · exonic.ai | still up |
| 2025-06-01 | YCb12 Labs Making hard molecules for Pharma and Biotech · b12-labs.com | still up |
| 2026-06-01 | AI-native pharma company · atlasdiscovery.bio | still up |
| 2020-06-01 | We break viruses · pardesbio.com | acquired |
| 2026-01-01 | Multimodal foundation models to predict uncollected patient biology · strandai.com | still up |
| 2020-01-01 | The better way to run single cell genomics · dropprintgen.com | acquired |
| 2024-06-01 | Converting biology into digital molecular maps · biocartesian.com | still up |
| 2020-01-01 | Menten AI designs peptide and protein therapeutics using quantum… · menten.ai | still up |
| 2026-01-01 | YCCellType The agentic drug company. We simulate human biology. · celltype.com | still up |
| 2015-06-01 | Patient-derived 3D tissue reconstruction models for preclinical… · zpredicta.com | acquired |
| 2018-06-01 | Synkrino's AI, SATIS is a powerful, unbiased discovery system for… · synkrino.bio | still up |
| 2026-06-01 | YCGamgee Curing cancer. Starting with dogs. · gamgee.io | still up |
| 2016-01-01 | YCPerlara Perlara: building the YC for rare disease parents · perlara.com | still up |
| 2026-06-01 | YCTareBio Vaccines for any cancer or infection in weeks. · tarebio.com | still up |
| 2020-06-01 | Accelerating protein engineering. · trident.bio | gone |
| 2022-06-01 | YCKeylika Redefining the Standard of Care for Iron Deficiency Anemia · keylika.com | still up |
| 2019-06-01 | Household needs, from bread to everything. · breadfast.com | still up |
How this compares
Older launches have had longer to die, so this slope is expected. A year that broke it would mean something is wrong with the checking.
The register re-probes every domain it holds. Some that answered last month stop answering. We send that list — what went quiet, and what it was — once a month. Nothing else.
How this was made. Show HN entries are every post from 2021 to 2023 with at least five points that linked to its own domain; code hosts and free hosting are excluded, because a repository outlives the effort behind it. Product Hunt entries needed 100 votes — a far higher bar, so they are the promoted top slice rather than a like-for-like sample. Both are judged by asking the domain whether it still answers: gone means it no longer resolves, refuses the connection, serves a parking page, or says plainly that it shut down. An HTTP error is not counted as gone — a server answering 404 is one somebody still pays for, and an audit of 25 gone-calls found two such sites alive with only a moved homepage. Y Combinator entries use the status YC publishes itself, which is why only those can say acquired. Squatted domains — a lapsed name now serving somebody else's site — are not detected, so these figures run slightly low.