You asked about Drug Delivery
197 people built something like it. 34 are gone.
That is 20% of the ones whose fate we could settle, against 23% across the whole register. 26 were acquired.
| Launched | What it was | Today |
|---|---|---|
| 2015-01-01 | Artificial intelligence for drug discovery. · numerionlabs.ai | still up |
| 2019-06-01 | Discovering the true signals of disease to power life-changing drugs. · sequencebio.com | still up |
| 2015-06-01 | We use human data and AI to develop better drugs faster. · vergegenomics.com | still up |
| 2020-01-01 | YCPostEra Medicinal Chemistry powered by Machine Learning · postera.ai | still up |
| 2022-01-01 | Unleashing the potential of DNA and RNA based therapies using AI · whitelabgx.com | still up |
| 2018-01-01 | Delivering RNA therapies. · sixfold.bio | still up |
| 2021-06-01 | YCAdaptyv We're building fully automated labs for protein engineering · adaptyvbio.com | still up |
| 2017-01-01 | Next-generation mRNA platform to solve cancer, COVID and climate. · helixnano.com | still up |
| 2019-06-01 | Arpeggio Bio develops drugs targeting transcription factors using AI… · arpeggiobio.com | still up |
| 2021-06-01 | Using the immune system to cure disease · parallel.bio | still up |
| 2021-06-01 | Discovering drugs that target the DNA regulome · talus.bio | still up |
| 2020-01-01 | Using CRISPR to find treatments for cancer and inflammation · algenbio.com | still up |
| 2020-01-01 | The next generation of induced-proximity medicines. · generalproximity.bio | still up |
| 2020-06-01 | Gilgamesh Pharmaceuticals, a Clinical stage biotechnology company… · gilgameshpharmaceutical.com | still up |
| 2020-01-01 | We create activating antibodies to treat diseases others can’t. · abalonebio.com | still up |
| 2018-01-01 | Computational antibody design · macromoltek.com | still up |
| 2023-01-01 | Generative AI for protein design · diffuse.bio | still up |
| 2021-06-01 | We make injections as easy as pushing a button! · pirouettepharma.com | still up |
| 2018-01-01 | Skin patches for generic drug delivery. · avrolifesci.com | still up |
| 2021-06-01 | Multi-targeted therapeutics to treat complex diseases · harmonicdiscovery.com | still up |
| 2020-06-01 | We use AI to design antibodies for intractable diseases · nabla.bio | still up |
| 2021-06-01 | The foundation for the next era of biology · outputbio.com | still up |
| 2023-01-01 | YCMiracle Accelerate clinical trials with real-time, actionable insights · miracleml.com | still up |
| 2021-06-01 | Programmable biology company for psychoactive effect design · mindstate.design | still up |
| 2023-01-01 | Adventris makes cancer vaccines · adventris.com | still up |
| 2020-01-01 | We’re creating programmable therapies · felixbt.com | gone |
| 2023-01-01 | Developing long-lasting drug formulations 50% faster · persist-ai.com | still up |
| 2023-01-01 | YCInvitris Creating new protein-based drugs at scale · invitris.com | still up |
| 2023-01-01 | Empowering every doctor and every patient to participate in research · novel.care | still up |
| 2024-06-01 | Gen AI molecular simulations that reproduce wetlab results · angstrom-ai.com | still up |
| 2018-06-01 | New clinical tests for managing autoimmune treatments. · coralgenomics.com | acquired |
| 2017-01-01 | Enabling T cell immunotherapy discovery, development and manufacturing · indeelabs.com | still up |
| 2023-06-01 | Combination therapeutics for the world's toughest diseases · oliolabs.co | still up |
| 2023-06-01 | YCNanograb Deliver genes to any cell with AI · nanograb.com | still up |
| 2022-06-01 | YCQuinn Your biopharma team, from molecule design to portfolio strategy · quinnbio.com | still up |
| 2021-06-01 | Developing milk-inspired therapeutics for infectious diseases · matrubials.com | still up |
| 2019-01-01 | Smart gels for local drug delivery to the gut · intacttherapeutics.com | still up |
| 2025-06-01 | YCConvexia The world's first AI-maximalist pharma company · convexia.bio | still up |
| 2021-06-01 | The dynamic single-cell analysis company · cellchorus.com | still up |
| 2026-01-01 | YCOrigin AI and Data for Cancer Therapeutics · origin.bio | still up |
| 2022-01-01 | Growing micro-organs to find new drugs · rosebudbiosciences.com | still up |
| 2025-06-01 | YCb12 Labs Making hard molecules for Pharma and Biotech · b12-labs.com | still up |
| 2026-01-01 | Evolutionary intelligence for autoimmune disease · dittobio.com | still up |
| 2023-01-01 | AI for drug formulation · lavo.ai | gone |
| 2025-09-01 | YCExonic Exonic is an AI-native cell and gene therapeutics company. · exonic.ai | still up |
| 2026-06-01 | AI-native pharma company · atlasdiscovery.bio | still up |
| 2024-06-01 | Converting biology into digital molecular maps · biocartesian.com | still up |
| 2020-06-01 | We break viruses · pardesbio.com | acquired |
| 2026-01-01 | Multimodal foundation models to predict uncollected patient biology · strandai.com | still up |
| 2020-01-01 | The better way to run single cell genomics · dropprintgen.com | acquired |
| 2026-06-01 | YCGamgee Curing cancer. Starting with dogs. · gamgee.io | still up |
| 2020-01-01 | Menten AI designs peptide and protein therapeutics using quantum… · menten.ai | still up |
| 2015-06-01 | Patient-derived 3D tissue reconstruction models for preclinical… · zpredicta.com | acquired |
| 2018-06-01 | Synkrino's AI, SATIS is a powerful, unbiased discovery system for… · synkrino.bio | still up |
| 2026-01-01 | YCCellType The agentic drug company. We simulate human biology. · celltype.com | still up |
| 2016-01-01 | YCPerlara Perlara: building the YC for rare disease parents · perlara.com | still up |
| 2026-06-01 | YCTareBio Vaccines for any cancer or infection in weeks. · tarebio.com | still up |
| 2020-06-01 | Accelerating protein engineering. · trident.bio | gone |
| 2022-06-01 | YCKeylika Redefining the Standard of Care for Iron Deficiency Anemia · keylika.com | still up |
| 2019-06-01 | Household needs, from bread to everything. · breadfast.com | still up |
How this compares
Y Combinator reports its own outcomes, including acquisitions. The other two are judged by asking the domain, so they are not measured the same way and are never averaged together.
Older launches have had longer to die, so this slope is expected. A year that broke it would mean something is wrong with the checking.
The register re-probes every domain it holds. Some that answered last month stop answering. We send that list — what went quiet, and what it was — once a month. Nothing else.
How this was made. Show HN entries are every post from 2021 to 2023 with at least five points that linked to its own domain; code hosts and free hosting are excluded, because a repository outlives the effort behind it. Product Hunt entries needed 100 votes — a far higher bar, so they are the promoted top slice rather than a like-for-like sample. Both are judged by asking the domain whether it still answers: gone means it no longer resolves, refuses the connection, serves a parking page, or says plainly that it shut down. An HTTP error is not counted as gone — a server answering 404 is one somebody still pays for, and an audit of 25 gone-calls found two such sites alive with only a moved homepage. Y Combinator entries use the status YC publishes itself, which is why only those can say acquired. Squatted domains — a lapsed name now serving somebody else's site — are not detected, so these figures run slightly low.