You asked about IoT
34 people built something like it. 3 are gone.
That is 10% of the ones whose fate we could settle, against 23% across the whole register. 3 were acquired.
| Launched | What it was | Today |
|---|---|---|
| 2021-01-01 | YCTractian Physical AI for asset-heavy industries · tractian.com | still up |
| 2022-01-01 | Plug-and-play AI platform with sensors and dashboards that makes… · iotflows.com | still up |
| 2019-01-01 | YCOverview Reshaping industrial quality with AI, hardware, and software · overview.ai | still up |
| 2019-06-01 | Arpeggio Bio develops drugs targeting transcription factors using AI… · arpeggiobio.com | still up |
| 2020-01-01 | YCPowerX AI powered sensors that save energy, water and emissions · powerx.co | acquired |
| 2024-01-01 | AI Inference Platform for Drug Discovery · tamarind.bio | still up |
| 2025-01-01 | AI powered operating system for distributors and OEMs · salespatriot.com | still up |
| 2019-01-01 | In-store analytics AI assistant to fix your retail stores · auravision.ai | still up |
| 2023-01-01 | Generative AI for protein design · diffuse.bio | still up |
| 2022-06-01 | YCLamin Open data platform for traceable, multimodal AI · lamin.ai | still up |
| 2025-01-01 | AI drug discovery platform for neurotherapeutics · exintherapeutics.com | still up |
| 2022-01-01 | YCHypaHub A Cloud-Based Bioinformatics and AI Platform · hypahub.com | acquired |
| 2021-06-01 | AI-designed Affinity Reagents · medium.bio | still up |
| 2024-06-01 | Gen AI molecular simulations that reproduce wetlab results · angstrom-ai.com | still up |
| 2023-06-01 | YCNanograb Deliver genes to any cell with AI · nanograb.com | still up |
| 2023-01-01 | Gen-AI Designed Enzymes for Pharmaceutical Innovation · pando.bio | still up |
| 2026-01-01 | The AI-native platform for next-generation protein characterization. · 10xscience.com | still up |
| 2025-06-01 | YCConvexia The world's first AI-maximalist pharma company · convexia.bio | still up |
| 2025-06-01 | AI infrastructure for biosecurity · twentytwo.bio | still up |
| 2024-09-01 | AI for life sciences documents · raycaster.ai | still up |
| 2024-06-01 | The AI scientist for always-on biodefense · aminoanalytica.com | still up |
| 2023-01-01 | AI for drug formulation · lavo.ai | gone |
| 2026-01-01 | YCRitivel AI-native platform for Life-Sciences Documentation · ritivel.com | still up |
| 2026-06-01 | YCWonderTx Extrapolative AI to unlock First-in-Class drugs · wondertx.ai | still up |
| 2026-06-01 | AI-native pharma company · atlasdiscovery.bio | still up |
| 2025-06-01 | Implantable microchips and AI for cattle monitoring · nexa.farm | acquired |
| 2026-06-01 | YCOsseus The frontier data platform for health and biological AI · osseus.ai | still up |
| 2024-06-01 | AI document creation and data management for clinical trials · baselinetrials.com | gone |
| 2026-06-01 | We are a multi-strategy trading firm that trains AI traders. · spectreintelligence.ai | still up |
| 2024-09-01 | Scaling Genomic AI for Embryo Selection · reticular.com | still up |
| 2018-06-01 | Synkrino's AI, SATIS is a powerful, unbiased discovery system for… · synkrino.bio | still up |
| 2015-01-01 | YC20n Using AI to predict biochemistry for manufacturing and therapeutics · 20n.com | gone |
| 2019-06-01 | AI platform accelerating therapies for rare & inflammatory diseases. · gen1e.com | still up |
| 2024-06-01 | An AI agent for scientific research · undermind.ai | still up |
How this compares
The register re-probes every domain it holds. Some that answered last month stop answering. We send that list — what went quiet, and what it was — once a month. Nothing else.
How this was made. Show HN entries are every post from 2021 to 2023 with at least five points that linked to its own domain; code hosts and free hosting are excluded, because a repository outlives the effort behind it. Product Hunt entries needed 100 votes — a far higher bar, so they are the promoted top slice rather than a like-for-like sample. Both are judged by asking the domain whether it still answers: gone means it no longer resolves, refuses the connection, serves a parking page, or says plainly that it shut down. An HTTP error is not counted as gone — a server answering 404 is one somebody still pays for, and an audit of 25 gone-calls found two such sites alive with only a moved homepage. Y Combinator entries use the status YC publishes itself, which is why only those can say acquired. Squatted domains — a lapsed name now serving somebody else's site — are not detected, so these figures run slightly low.