You asked about Genetic Engineering
222 people built something like it. 18 are gone.
That is 9% of the ones whose fate we could settle, against 23% across the whole register. 16 were acquired.
| Launched | What it was | Today |
|---|---|---|
| 2016-06-01 | YCScale AI Data-centric infrastructure to accelerate the development of AI · scale.com | still up |
| 2016-01-01 | YCSendbird The AI agent that doesn’t just support, it delights. · sendbird.com | still up |
| 2016-01-01 | AI + Robotics for the Built World · geckorobotics.com | still up |
| 2023-08-07 | chainforge.ai | still up |
| 2019-06-01 | YCCoLab Human and AI design review for hardware · colabsoftware.com | still up |
| 2016-01-01 | YCDeepgram Building foundational AI for speech transcription and understanding. · deepgram.com | still up |
| 2020-01-01 | YCAirbyte Context layer for production-grade AI agents · airbyte.com | still up |
| 2022-01-01 | AI-native operating system for home service businesses · broccoli.com | still up |
| 2019-01-01 | Superb AI provides end-to-end computer vision MLOps platform · superb-ai.com | still up |
| 2021-06-01 | YCVerihubs AI-powered Deepfake Detection · verihubs.com | still up |
| 2021-01-01 | YCMindee AI Document Understanding API · mindee.com | still up |
| 2020-06-01 | YCLuminai Luminai is the AI platform for Health System Operations. · luminai.com | still up |
| 2024-06-01 | AI Agents for collections · domu.ai | still up |
| 2021-01-01 | YCVapi Voice AI for developers. · vapi.ai | still up |
| 2015-01-01 | Paperspace is a cloud platform for building and scaling AI… · paperspace.com | acquired |
| 2023-01-01 | YCPirros AI Platform for Architects and Engineers · pirros.com | still up |
| 2018-01-01 | YCVeriff AI-powered identity verification solution for fraud prevention. · veriff.com | still up |
| 2022-01-01 | Compliant-Ready AI for the Enterprise · dynamo.ai | still up |
| 2022-01-01 | YCBotCity Observability and Governance for AI-Generated Python scripts. · botcity.dev | still up |
| 2022-01-01 | YCLanceDB Open-source, serverless vectordb for production-scale generative AI · lancedb.com | still up |
| 2020-06-01 | AI-powered user assistance platform · command.ai | acquired |
| 2024-01-01 | YCGreptile AI code review agent with complete context of your codebase · greptile.com | still up |
| 2024-01-01 | Accelerate Medication Access with AI · runtrellis.com | still up |
| 2021-01-01 | YCauthzed Authorization Infrastructure securing AI at OpenAI, Zoom, & more · authzed.com | still up |
| 2020-06-01 | YCDatafold Automating manual and repetitive data engineering tasks with AI · datafold.com | still up |
| 2025-01-01 | YCMastra The Javascript framework for building AI agents, from the Gatsby devs · mastra.ai | still up |
| 2023-06-01 | YCGiga AI Support Agent for Enterprises. · giga.ai | still up |
| 2021-06-01 | YCSecoda Secoda is the AI layer for your Analytics · secoda.co | still up |
| 2024-01-01 | Autonomous offensive and defensive cybersecurity platform · codeant.ai | still up |
| 2021-06-01 | YCMach9 AI CAD Software for Civil Engineering · mach9.ai | still up |
| 2021-06-01 | The fastest way to ship airtight AI · openlayer.com | still up |
| 2015-06-01 | AI-assisted electronics design · snapmagic.com | still up |
| 2020-01-01 | YCNextmv A DecisionOps platform that accelerates optimization AI teams · nextmv.io | acquired |
| 2024-01-01 | YCOpen Enterprise AI customer support · open.cx | still up |
| 2023-06-01 | YCTiptap The open-source document editor for humans and AI agents. · tiptap.dev | still up |
| 2023-01-01 | YCLangfuse Open source LLM engineering platform · langfuse.com | acquired |
| 2021-06-01 | YCAbstra Automate finance operations with Python and AI · abstra.io | still up |
| 2023-01-01 | YCInkeep Build AI Agent teammates and automations in code or no-code · inkeep.com | still up |
| 2023-01-29 | dystr.com | still up |
| 2024-09-01 | YCCekura Voice AI and Chat AI agents: Testing and Observability · cekura.ai | still up |
| 2025-06-01 | YCF2 The AI platform for private markets investors · f2.ai | still up |
| 2022-06-01 | YCIntuned Code-first scrapers and RPAs — built and maintained by AI · intunedhq.com | still up |
| 2024-06-01 | YCEntangl Find & resolve issues in data center engineering & operations using AI · entangl.com | still up |
| 2021-06-01 | Affogato AI — Your Agent for instant TikToks, Reels, and ads. · affogato.ai | still up |
| 2021-06-01 | AI native mobile testing. · mobileboost.io | still up |
| 2024-01-01 | YCDraftaid Go from 3D models to CAD drawings using AI · draftaid.io | still up |
| 2020-06-01 | Humanloop is the LLM evals platform for enterprises. · humanloop.com | acquired |
| 2025-01-01 | YCWeave AI to understand and then route engineering work · weaveos.com | still up |
| 2021-01-01 | YCWaydev Engineering intelligence for AI transformation · waydev.co | still up |
| 2015-01-01 | YCTara AI Meet Tara AI, your new engineering efficiency co-pilot. · tara.ai | still up |
| 2024-06-01 | YCZeit AI The autonomous data engineer for the mid-market · zeit-ai.com | still up |
| 2014-01-01 | YCWit.ai Natural Language for Developers --Wit is an API that makes it easy… · wit.ai | acquired |
| 2022-06-01 | YCLamin Open data platform for traceable, multimodal AI · lamin.ai | still up |
| 2024-06-01 | Automate circuit board design using AI · diode.computer | still up |
| 2023-06-01 | AI for Government Contracting. · sweetspot.so | still up |
| 2025-09-01 | YCMOVEdot AI Agents for Hardware Engineering · movedot.ai | still up |
| 2024-06-01 | YCCoval Simulation & Evaluation that scales voice and chat AI agents · coval.dev | still up |
| 2023-01-01 | Go from idea to production with AI. · magicpatterns.com | still up |
| 2021-06-01 | Plan and review AI generated code · vibekanban.com | still up |
| 2025-06-01 | YCWafer AI that makes AI fast · wafer.ai | still up |
How this compares
Y Combinator reports its own outcomes, including acquisitions. The other two are judged by asking the domain, so they are not measured the same way and are never averaged together.
Older launches have had longer to die, so this slope is expected. A year that broke it would mean something is wrong with the checking.
The register re-probes every domain it holds. Some that answered last month stop answering. We send that list — what went quiet, and what it was — once a month. Nothing else.
How this was made. Show HN entries are every post from 2021 to 2023 with at least five points that linked to its own domain; code hosts and free hosting are excluded, because a repository outlives the effort behind it. Product Hunt entries needed 100 votes — a far higher bar, so they are the promoted top slice rather than a like-for-like sample. Both are judged by asking the domain whether it still answers: gone means it no longer resolves, refuses the connection, serves a parking page, or says plainly that it shut down. An HTTP error is not counted as gone — a server answering 404 is one somebody still pays for, and an audit of 25 gone-calls found two such sites alive with only a moved homepage. Y Combinator entries use the status YC publishes itself, which is why only those can say acquired. Squatted domains — a lapsed name now serving somebody else's site — are not detected, so these figures run slightly low.