You asked about Anti-Aging
30 people built something like it. 11 are gone.
That is 41% of the ones whose fate we could settle, against 23% across the whole register. 3 were acquired.
| Launched | What it was | Today |
|---|---|---|
| 2021-06-01 | Regulating the immune system to block cancer & autoimmune diseases · sfatherapeutics.com | still up |
| 2021-01-01 | Longevity Nutrition Service · eatblueprint.com | gone |
| 2021-01-01 | YCLygg Building New Anti-Aging Ingredients for Skincare · lyggcorp.com | still up |
| 2021-10-12 | visionzeroreporting.com | still up |
| 2021-01-06 | reslash.co | unverified |
| 2021-12-14 | pinecone.io | still up |
| 2021-01-07 | chordata.cc | unverified |
| 2021-01-06 | artifacts.bypaulshen.com | unverified |
| 2021-06-09 | airy.co | still up |
| 2021-06-25 | sirendns.com | gone |
| 2021-07-12 | silverdial.org | gone |
| 2021-08-09 | padka.com | gone |
| 2021-01-01 | Plaid for Southeast Asia · finantier.co | gone |
| 2021-06-01 | YCBolster The platform for buying, selling and managing residential construction · bolsterbuilt.com | still up |
| 2021-09-22 | alovingexploration.com | still up |
| 2021-02-23 | quill.chat | gone |
| 2021-06-01 | YCUnion54 Developers of ChitChat, an integrated messaging and payments wallet… · union54.com | still up |
| 2021-01-10 | ephemere.app | gone~22mo |
| 2021-06-01 | Moving Things Around in Space, Imaging Space Objects When We're Not · turionspace.com | still up |
| 2021-01-01 | Discovering bispecific antibody drug-conjugates (BsADC) against cancer · valinktx.com | still up |
| 2021-09-26 | mantis.chat | gone |
| 2021-06-06 | dontwaste.today | gone |
| 2021-06-16 | joinportal.com | moved |
| 2021-03-04 | quantifynow.app | still up |
| 2021-06-25 | birdslate.com | still up |
| 2021-01-01 | YCPipeBio PipeBio is a SaaS bioinformatics platform to develop antibody drugs. · pipebio.com | acquired |
| 2021-02-27 | mebeam.com | unverified |
| 2021-01-01 | Analyzing EHR and messaging data to predict disease before it occurs. · quadrant.health | still up |
| 2021-02-17 | tardamail.com | gone~49mo |
| 2021-01-01 | YCPingPong Video messaging app for remote teams. · getpingpong.com | acquired |
| 2021-03-10 | things.morflax.com | still up |
| 2021-06-15 | fiotron.com | still up |
| 2021-03-12 | superpage.to | unverified |
| 2021-06-01 | YCHilos Close and activate your customers on WhatsApp · hilos.io | acquired |
| 2021-06-01 | One-hour antibiotic sensitivity testing · astekdx.com | still up |
| 2021-01-01 | We help run engaging online conferences. · meetanyway.com | gone |
How this compares
Y Combinator reports its own outcomes, including acquisitions. The other two are judged by asking the domain, so they are not measured the same way and are never averaged together.
The register re-probes every domain it holds. Some that answered last month stop answering. We send that list — what went quiet, and what it was — once a month. Nothing else.
How this was made. Show HN entries are every post from 2021 to 2023 with at least five points that linked to its own domain; code hosts and free hosting are excluded, because a repository outlives the effort behind it. Product Hunt entries needed 100 votes — a far higher bar, so they are the promoted top slice rather than a like-for-like sample. Both are judged by asking the domain whether it still answers: gone means it no longer resolves, refuses the connection, serves a parking page, or says plainly that it shut down. An HTTP error is not counted as gone — a server answering 404 is one somebody still pays for, and an audit of 25 gone-calls found two such sites alive with only a moved homepage. Y Combinator entries use the status YC publishes itself, which is why only those can say acquired. Squatted domains — a lapsed name now serving somebody else's site — are not detected, so these figures run slightly low.