You asked about AI-powered Drug Discovery
406 people built something like it. 90 are gone.
That is 23% of the ones whose fate we could settle, against 23% across the whole register. Half of the gone ones were last seen within 20 months of launching. 22 were acquired.
| Launched | What it was | Today |
|---|---|---|
| 2021-06-01 | YCAdaptyv We're building fully automated labs for protein engineering · adaptyvbio.com | still up |
| 2021-06-01 | Using the immune system to cure disease · parallel.bio | still up |
| 2021-01-01 | YCPipeBio PipeBio is a SaaS bioinformatics platform to develop antibody drugs. · pipebio.com | acquired |
| 2021-06-01 | The foundation for the next era of biology · outputbio.com | still up |
| 2021-06-01 | Multi-targeted therapeutics to treat complex diseases · harmonicdiscovery.com | still up |
| 2021-06-01 | The dynamic single-cell analysis company · cellchorus.com | still up |
| 2021-06-01 | Developing milk-inspired therapeutics for infectious diseases · matrubials.com | still up |
| 2021-06-01 | Regulating the immune system to block cancer & autoimmune diseases · sfatherapeutics.com | still up |
| 2021-01-01 | Discovering bispecific antibody drug-conjugates (BsADC) against cancer · valinktx.com | still up |
| 2021-06-01 | Programmable biology company for psychoactive effect design · mindstate.design | still up |
| 2021-03-16 | about.cryptotask.org | still up |
| 2021-01-03 | headlime.com | still up |
| 2021-06-01 | YCVerihubs AI-powered Deepfake Detection · verihubs.com | still up |
| 2021-01-01 | YCHumaans AI-Powered HRIS for high performing teams · humaans.io | still up |
| 2021-09-03 | examples.jina.ai | gone |
| 2021-01-01 | AI-powered customer service for startups · cloudhumans.com | still up |
| 2021-01-01 | YCMoichor AI Powered Animal Diagnostics · moichor.com | still up |
| 2021-01-01 | Generative AI powered Shopify for home service professionals · toplinepro.com | still up |
| 2021-02-04 | evertrove.co | unverified |
| 2021-01-01 | AI-powered Compliance Platform for PCI 4, CCPA, HIPAA, CIPA, 50+ laws · feroot.com | still up |
| 2021-01-01 | YCSpokn AI-powered video platform for Internal Comms and HR teams · getspokn.com | still up |
| 2021-06-01 | Discovering drugs that target the DNA regulome · talus.bio | still up |
| 2021-01-01 | Take Care of Shitty Paperwork for Expensive Drugs · lamarhealth.com | still up |
| 2021-06-01 | YCEpsilon3 AI-Powered ERP, MES, and Test Software for Complex Operations · epsilon3.io | still up |
| 2021-06-01 | YCidemeum AI-powered Application Control · idemeum.com | still up |
| 2021-06-01 | We make injections as easy as pushing a button! · pirouettepharma.com | still up |
| 2021-06-01 | AI-Powered Business Development for Scientific Organizations · firstignite.com | acquired |
| 2021-01-01 | Cut your writing time by 40% with AI-powered autocomplete · compose.ai | still up |
| 2021-09-30 | tangle.work | unverified |
| 2021-01-01 | Discover drugs that control how much cells "squeeze" to treat disease · forcytebio.com | gone |
| 2021-05-01 | namebatao.com | gone |
| 2021-06-01 | The complete production quality platform. AI-powered E2E testing,… · artillery.io | still up |
| 2021-06-01 | wordblot.ai | gone |
| 2021-06-01 | AI-powered equity research software · hudson-labs.com | still up |
| 2021-01-01 | Genetic Medicine with Small Molecules · serna.bio | still up |
| 2021-07-14 | booklyn.co | unverified |
| 2021-12-15 | explaincode.app | still up |
| 2021-06-24 | reviewr.ai | still up |
| 2021-01-01 | YCCodeball AI-Powered Code Review · codeball.ai | gone |
| 2021-06-01 | YCMentum AI-Powered Assistant for Procurement and Strategic Sourcing · getmentum.com | acquired |
| 2021-07-12 | obsidian.md | still up |
| 2021-01-01 | YCTractian Physical AI for asset-heavy industries · tractian.com | still up |
| 2021-06-01 | YCLemFi Fair, simple and accessible financial services · lemfi.com | still up |
| 2021-04-01 | mailstudio.app | still up |
| 2021-06-01 | YCShipBlu Amazon Level Logistics for eCommerce Companies in MENA. · shipblu.com | still up |
| 2021-12-29 | a9.io | still up |
| 2021-01-01 | YCVendease Where restaurants in Africa buy food supplies · vendease.com | still up |
| 2021-06-12 | landrop.app | still up |
| 2021-01-23 | rysolv.com | moved |
| 2021-08-18 | pop.com | still up |
| 2021-05-28 | ninfex.com | unverified |
| 2021-01-01 | YCCyble Cyble - World’s First Intelligence-Driven, AI-Native Security… · cyble.com | still up |
| 2021-06-26 | cq.mtc.dev | gone |
| 2021-10-03 | spotml.io | gone |
| 2021-01-01 | YCclicOH Amazon-like logistics for e-commerce companies in Latam · clicoh.com | still up |
| 2021-01-01 | YCGigs The OS for Embedded Telecom · gigs.com | still up |
| 2021-06-01 | One-stop-shop for restaurants to operate and grow their business. · pidedirecto.mx | still up |
| 2021-01-01 | YCEstoca The Logistics Operating System for E-commerce in LatAm · estoca.com.br | still up |
| 2021-01-01 | YCEncord The data layer for physical AI · encord.com | still up |
| 2021-08-24 | easyzoom.com | still up |
How this compares
Y Combinator reports its own outcomes, including acquisitions. The other two are judged by asking the domain, so they are not measured the same way and are never averaged together.
The register re-probes every domain it holds. Some that answered last month stop answering. We send that list — what went quiet, and what it was — once a month. Nothing else.
How this was made. Show HN entries are every post from 2021 to 2023 with at least five points that linked to its own domain; code hosts and free hosting are excluded, because a repository outlives the effort behind it. Product Hunt entries needed 100 votes — a far higher bar, so they are the promoted top slice rather than a like-for-like sample. Both are judged by asking the domain whether it still answers: gone means it no longer resolves, refuses the connection, serves a parking page, or says plainly that it shut down. An HTTP error is not counted as gone — a server answering 404 is one somebody still pays for, and an audit of 25 gone-calls found two such sites alive with only a moved homepage. Y Combinator entries use the status YC publishes itself, which is why only those can say acquired. Squatted domains — a lapsed name now serving somebody else's site — are not detected, so these figures run slightly low.