You asked about AI-powered Drug Discovery
331 people built something like it. 41 are gone.
That is 14% of the ones whose fate we could settle, against 23% across the whole register. 33 were acquired.
| Launched | What it was | Today |
|---|---|---|
| 2023-01-01 | Generative AI for protein design · diffuse.bio | still up |
| 2023-06-01 | YCNanograb Deliver genes to any cell with AI · nanograb.com | still up |
| 2023-01-01 | AI for drug formulation · lavo.ai | gone |
| 2023-01-01 | Developing long-lasting drug formulations 50% faster · persist-ai.com | still up |
| 2023-01-01 | AI Powered Product Discovery · rubberduckylabs.io | gone |
| 2023-01-01 | YCAvoca AI-powered Sales Agent for Service-Based Industries · avoca.ai | still up |
| 2023-06-01 | B2B debt collection powered by AI agents · agentcollect.com | still up |
| 2023-01-01 | AI-powered care for seniors with chronic disease · kivohealth.com | still up |
| 2023-01-01 | YCTruewind AI-Powered Accounting · truewind.ai | still up |
| 2023-06-01 | YCOutset AI-powered user interviews · outset.ai | still up |
| 2023-06-01 | YCCercli AI powered HR and Recruitment for people teams · cercli.com | still up |
| 2023-06-01 | YCBolto AI Powered All-In-One Payroll, HR + Recruiting · bolto.com | still up |
| 2023-01-01 | AI-Powered Super Mentor for Test Prep · superkalam.com | still up |
| 2023-06-01 | AI-powered risk and compliance for financial institutions · kobaltlabs.com | still up |
| 2023-06-01 | AI-powered insurance verification to boost patient conversion. · soharhealth.com | still up |
| 2023-01-01 | Maximize profits with AI-powered rebate management. · speedylabs.ai | still up |
| 2023-06-01 | YCTempo Visual Editor for React, powered by AI · tempo.new | still up |
| 2023-01-01 | AI-Powered Clinical Decision Support & Ambient Scribing · glass.health | still up |
| 2023-06-01 | YCGuac AI-powered forecasting & replenishment for grocery · guac.com | still up |
| 2023-01-01 | Adventris makes cancer vaccines · adventris.com | still up |
| 2023-01-01 | YCMiracle Accelerate clinical trials with real-time, actionable insights · miracleml.com | still up |
| 2023-01-01 | YCInvitris Creating new protein-based drugs at scale · invitris.com | still up |
| 2023-06-01 | Building the AI-powered marketing ops platform that turns website… · withsurface.com | still up |
| 2023-01-01 | Empowering every doctor and every patient to participate in research · novel.care | still up |
| 2023-06-01 | The AI-powered risk decision platform · trycatamaran.com | acquired |
| 2023-01-01 | YCPigeon AI-powered document automation: collect, review, extract, and sync. · pigeondocuments.com | still up |
| 2023-01-01 | YCOfOne AI-powered order taker for restaurant drive-thrus · of.one | acquired |
| 2023-06-01 | Combination therapeutics for the world's toughest diseases · oliolabs.co | still up |
| 2023-01-01 | AI-powered game translation. · magnaplay.com | still up |
| 2023-01-01 | YCOrchid AI-powered EHR for independent mental health professionals · orchid.health | still up |
| 2023-01-01 | YCFrigade AI-powered product assistance for modern software teams · frigade.com | still up |
| 2023-06-01 | YCRevamp AI-Powered Customer Segmentation for eCommerce · getrevamp.ai | still up |
| 2023-06-01 | AI-powered Infrastructure as Code PR reviews · tryterracotta.com | still up |
| 2023-06-01 | YCWatto AI AI-powered McKinsey-quality reports in seconds · watto.ai | acquired |
| 2023-06-01 | AI-Powered Medical Billing · quillbills.com | still up |
| 2023-01-01 | AI-powered customer support automation for fast-growing companies · opensight.ai | gone |
| 2023-01-01 | AI-powered data extraction engine · indexical.dev | gone |
| 2023-01-01 | YCPylon The Agentic Support Platform purpose-built for B2B. · usepylon.com | still up |
| 2023-01-01 | YCNumeral The AI-native sales tax solution. · numeral.com | still up |
| 2023-06-01 | YCCampfire The AI Native ERP for the fastest growing companies. · campfire.ai | still up |
| 2023-01-01 | YCHadrius Automating Securities Compliance · hadrius.com | still up |
| 2023-06-01 | Intelligence that runs your operations. · happyrobot.ai | still up |
| 2023-01-01 | YCWarp AI-native Employee Management Platform for High-Growth Companies · warp.co | still up |
| 2023-06-01 | End-to-end content, learning, & deal intelligence for B2B sales teams · letter.ai | still up |
| 2023-06-01 | YCBland AI The enterprise platform for AI phone calls · bland.com | still up |
| 2023-01-01 | YCStackAI The Enterprise AI Transformation Platform · stackai.com | acquired |
| 2023-01-01 | YCOnshore AI for corporate tax · onshore.com | still up |
| 2023-06-01 | YCLangdock The all-in-one AI platform for companies. · langdock.com | still up |
| 2023-06-01 | AI patent drafting, prosecution, litigation and more for legal teams. · solveintelligence.com | still up |
| 2023-06-01 | Digital-native home painting franchise · craftwork.com | still up |
| 2023-06-01 | YCVetRec AI Scribe for veterinarians. Saving time and improving patient care. · vetrec.io | still up |
| 2023-01-01 | YCResend Email for developers · resend.com | still up |
| 2023-01-01 | YCPirros AI Platform for Architects and Engineers · pirros.com | still up |
| 2023-01-01 | YCSalient AI Servicing for Auto Lenders · trysalient.com | still up |
| 2023-01-01 | YCVooma Automation platform for logistics · vooma.ai | still up |
| 2023-01-01 | AI-based full stack observability platform · middleware.io | still up |
| 2023-06-01 | YCHyLight Unmanned airships for inspecting our critical assets · hylight.aero | still up |
| 2023-01-01 | YCPlayAI Our mission is to make Voice AI accessible and useful to all. · play.ai | acquired |
| 2023-06-01 | AI-native operations for the banks · bretton.com | still up |
| 2023-06-01 | YCGiga AI Support Agent for Enterprises. · giga.ai | still up |
How this compares
The register re-probes every domain it holds. Some that answered last month stop answering. We send that list — what went quiet, and what it was — once a month. Nothing else.
How this was made. Show HN entries are every post from 2021 to 2023 with at least five points that linked to its own domain; code hosts and free hosting are excluded, because a repository outlives the effort behind it. Product Hunt entries needed 100 votes — a far higher bar, so they are the promoted top slice rather than a like-for-like sample. Both are judged by asking the domain whether it still answers: gone means it no longer resolves, refuses the connection, serves a parking page, or says plainly that it shut down. An HTTP error is not counted as gone — a server answering 404 is one somebody still pays for, and an audit of 25 gone-calls found two such sites alive with only a moved homepage. Y Combinator entries use the status YC publishes itself, which is why only those can say acquired. Squatted domains — a lapsed name now serving somebody else's site — are not detected, so these figures run slightly low.