You asked about AI-powered Drug Discovery
249 people built something like it. 30 are gone.
That is 13% of the ones whose fate we could settle, against 23% across the whole register. 22 were acquired.
| Launched | What it was | Today |
|---|---|---|
| 2021-06-01 | YCAdaptyv We're building fully automated labs for protein engineering · adaptyvbio.com | still up |
| 2021-06-01 | Using the immune system to cure disease · parallel.bio | still up |
| 2021-01-01 | YCPipeBio PipeBio is a SaaS bioinformatics platform to develop antibody drugs. · pipebio.com | acquired |
| 2021-06-01 | The foundation for the next era of biology · outputbio.com | still up |
| 2021-06-01 | Multi-targeted therapeutics to treat complex diseases · harmonicdiscovery.com | still up |
| 2021-06-01 | Regulating the immune system to block cancer & autoimmune diseases · sfatherapeutics.com | still up |
| 2021-06-01 | Developing milk-inspired therapeutics for infectious diseases · matrubials.com | still up |
| 2021-06-01 | The dynamic single-cell analysis company · cellchorus.com | still up |
| 2021-01-01 | Discovering bispecific antibody drug-conjugates (BsADC) against cancer · valinktx.com | still up |
| 2021-06-01 | Programmable biology company for psychoactive effect design · mindstate.design | still up |
| 2021-06-01 | YCVerihubs AI-powered Deepfake Detection · verihubs.com | still up |
| 2021-01-01 | YCHumaans AI-Powered HRIS for high performing teams · humaans.io | still up |
| 2021-01-01 | AI-powered customer service for startups · cloudhumans.com | still up |
| 2021-01-01 | YCMoichor AI Powered Animal Diagnostics · moichor.com | still up |
| 2021-01-01 | Generative AI powered Shopify for home service professionals · toplinepro.com | still up |
| 2021-01-01 | AI-powered Compliance Platform for PCI 4, CCPA, HIPAA, CIPA, 50+ laws · feroot.com | still up |
| 2021-01-01 | YCSpokn AI-powered video platform for Internal Comms and HR teams · getspokn.com | still up |
| 2021-06-01 | Discovering drugs that target the DNA regulome · talus.bio | still up |
| 2021-01-01 | Take Care of Shitty Paperwork for Expensive Drugs · lamarhealth.com | still up |
| 2021-06-01 | YCEpsilon3 AI-Powered ERP, MES, and Test Software for Complex Operations · epsilon3.io | still up |
| 2021-06-01 | YCidemeum AI-powered Application Control · idemeum.com | still up |
| 2021-06-01 | We make injections as easy as pushing a button! · pirouettepharma.com | still up |
| 2021-06-01 | AI-Powered Business Development for Scientific Organizations · firstignite.com | acquired |
| 2021-01-01 | Cut your writing time by 40% with AI-powered autocomplete · compose.ai | still up |
| 2021-06-01 | The complete production quality platform. AI-powered E2E testing,… · artillery.io | still up |
| 2021-01-01 | Discover drugs that control how much cells "squeeze" to treat disease · forcytebio.com | gone |
| 2021-06-01 | AI-powered equity research software · hudson-labs.com | still up |
| 2021-01-01 | Genetic Medicine with Small Molecules · serna.bio | still up |
| 2021-01-01 | YCCodeball AI-Powered Code Review · codeball.ai | gone |
| 2021-06-01 | YCMentum AI-Powered Assistant for Procurement and Strategic Sourcing · getmentum.com | acquired |
| 2021-01-01 | YCTractian Physical AI for asset-heavy industries · tractian.com | still up |
| 2021-06-01 | YCLemFi Fair, simple and accessible financial services · lemfi.com | still up |
| 2021-06-01 | YCShipBlu Amazon Level Logistics for eCommerce Companies in MENA. · shipblu.com | still up |
| 2021-01-01 | YCVendease Where restaurants in Africa buy food supplies · vendease.com | still up |
| 2021-01-01 | YCCyble Cyble - World’s First Intelligence-Driven, AI-Native Security… · cyble.com | still up |
| 2021-01-01 | YCclicOH Amazon-like logistics for e-commerce companies in Latam · clicoh.com | still up |
| 2021-06-01 | One-stop-shop for restaurants to operate and grow their business. · pidedirecto.mx | still up |
| 2021-01-01 | YCEstoca The Logistics Operating System for E-commerce in LatAm · estoca.com.br | still up |
| 2021-01-01 | YCEncord The data layer for physical AI · encord.com | still up |
| 2021-01-01 | YCGigs The OS for Embedded Telecom · gigs.com | still up |
| 2021-01-01 | YCAbacum The AI-native FP&A platform that helps Finance teams drive business… · abacum.ai | still up |
| 2021-01-01 | YCPibit.ai The fastest path from submission to better decisions. · pibit.ai | still up |
| 2021-01-01 | Tools & infra to build and scale high-quality blockchain applications. · quicknode.com | still up |
| 2021-06-01 | YCStepful Online Training for Healthcare Jobs · stepful.com | still up |
| 2021-01-01 | YCCodingal Leading online after-school for kids & teens to learn AI & coding · codingal.com | still up |
| 2021-01-01 | YCAlokai Frontend Platform for eCommerce · alokai.com | still up |
| 2021-01-01 | YCgaiia all-in-one operating system (OS) for telcos · gaiia.com | still up |
| 2021-01-01 | YCFathom The most flexible AI meeting notetaker ever built. · fathom.ai | still up |
| 2021-01-01 | Building the next generation AI creative studio · moonvalley.com | still up |
| 2021-01-01 | YCZ1 Digital bank for teenagers in LatAm connected to prepaid card · z1.app | still up |
| 2021-06-01 | YCTavus Building the human layer of AI · tavus.io | still up |
| 2021-06-01 | YCRootly AI-native on-call and incident response carefully crafted to help… · rootly.com | still up |
| 2021-06-01 | YCExa Web search rebuilt for LLMs · exa.ai | still up |
| 2021-01-01 | YCMeru.com The one-stop-shop for auto-parts in Mexico. · meru.com | still up |
| 2021-06-01 | YCAnakin One API to get clean data from any website for your AI agents at scale · anakin.io | still up |
| 2021-06-01 | YCMailmodo No-code email marketing platform to send forms & widgets within emails · mailmodo.com | acquired |
| 2021-06-01 | YCSlash Banking, corporate cards, stablecoin payments – available globally. · slash.com | still up |
| 2021-06-01 | YCConfido AI-enabled financial automation and intelligence for CPG Brands · confidotech.com | still up |
| 2021-06-01 | YCSwipe Super AI Accountant for SMBs · getswipe.in | still up |
| 2021-01-01 | YCMindee AI Document Understanding API · mindee.com | still up |
How this compares
The register re-probes every domain it holds. Some that answered last month stop answering. We send that list — what went quiet, and what it was — once a month. Nothing else.
How this was made. Show HN entries are every post from 2021 to 2023 with at least five points that linked to its own domain; code hosts and free hosting are excluded, because a repository outlives the effort behind it. Product Hunt entries needed 100 votes — a far higher bar, so they are the promoted top slice rather than a like-for-like sample. Both are judged by asking the domain whether it still answers: gone means it no longer resolves, refuses the connection, serves a parking page, or says plainly that it shut down. An HTTP error is not counted as gone — a server answering 404 is one somebody still pays for, and an audit of 25 gone-calls found two such sites alive with only a moved homepage. Y Combinator entries use the status YC publishes itself, which is why only those can say acquired. Squatted domains — a lapsed name now serving somebody else's site — are not detected, so these figures run slightly low.