You asked about AI-powered Drug Discovery
2,639 people built something like it. 305 are gone.
That is 13% of the ones whose fate we could settle, against 23% across the whole register. 211 were acquired.
| Launched | What it was | Today |
|---|---|---|
| 2015-01-01 | Artificial intelligence for drug discovery. · numerionlabs.ai | still up |
| 2020-01-01 | YCPostEra Medicinal Chemistry powered by Machine Learning · postera.ai | still up |
| 2016-01-01 | YCQvin Empowering women. Period. · qvin.com | still up |
| 2018-01-01 | Engineering next-generation, brain-penetrant cancer therapies. · reverielabs.com | gone |
| 2021-06-01 | YCAdaptyv We're building fully automated labs for protein engineering · adaptyvbio.com | still up |
| 2024-01-01 | AI Inference Platform for Drug Discovery · tamarind.bio | still up |
| 2021-06-01 | Using the immune system to cure disease · parallel.bio | still up |
| 2019-01-01 | YC1910 Multimodal AI Platform for Modality Agnostic Drug Discovery™ · 1910.ai | still up |
| 2020-06-01 | Combining 3D cell culture & AI to translate drugs to clinical success · knownmed.com | acquired |
| 2019-01-01 | We solve drug resistance for cancer · resistance.bio | gone |
| 2018-01-01 | Computational antibody design · macromoltek.com | still up |
| 2010-06-01 | YCTeevox Teevox · teevox.com | gone |
| 2021-01-01 | YCPipeBio PipeBio is a SaaS bioinformatics platform to develop antibody drugs. · pipebio.com | acquired |
| 2023-01-01 | Generative AI for protein design · diffuse.bio | still up |
| 2020-06-01 | We use AI to design antibodies for intractable diseases · nabla.bio | still up |
| 2021-06-01 | The foundation for the next era of biology · outputbio.com | still up |
| 2021-06-01 | Multi-targeted therapeutics to treat complex diseases · harmonicdiscovery.com | still up |
| 2018-01-01 | We are using the gut microbiome to end cancer. · persephonebiosciences.com | still up |
| 2020-01-01 | Altay develops disease-modifying therapies targeting transcription… · altaytherapeutics.com | still up |
| 2023-06-01 | YCNanograb Deliver genes to any cell with AI · nanograb.com | still up |
| 2024-06-01 | Gen AI molecular simulations that reproduce wetlab results · angstrom-ai.com | still up |
| 2021-06-01 | Developing milk-inspired therapeutics for infectious diseases · matrubials.com | still up |
| 2019-06-01 | YCShiru Shiru leverages ML to create proteins to feed the world sustainably. · shiru.com | still up |
| 2021-06-01 | Regulating the immune system to block cancer & autoimmune diseases · sfatherapeutics.com | still up |
| 2025-06-01 | YCConvexia The world's first AI-maximalist pharma company · convexia.bio | still up |
| 2021-06-01 | The dynamic single-cell analysis company · cellchorus.com | still up |
| 2023-01-01 | AI for drug formulation · lavo.ai | gone |
| 2026-06-01 | YCWonderTx Extrapolative AI to unlock First-in-Class drugs · wondertx.ai | still up |
| 2026-06-01 | AI-native pharma company · atlasdiscovery.bio | still up |
| 2022-01-01 | Growing micro-organs to find new drugs · rosebudbiosciences.com | still up |
| 2025-06-01 | YCb12 Labs Making hard molecules for Pharma and Biotech · b12-labs.com | still up |
| 2026-09-01 | Maximum information per experiment, minimum experiments per conclusion · halmoslabs.com | still up |
| 2024-06-01 | Making Next-Generation Antibiotics that Outpace Bacterial Evolution · evolverebiosciences.com | still up |
| 2018-06-01 | Synkrino's AI, SATIS is a powerful, unbiased discovery system for… · synkrino.bio | still up |
| 2020-01-01 | Menten AI designs peptide and protein therapeutics using quantum… · menten.ai | still up |
| 2022-06-01 | YCKeylika Redefining the Standard of Care for Iron Deficiency Anemia · keylika.com | still up |
| 2015-06-01 | We use human data and AI to develop better drugs faster. · vergegenomics.com | still up |
| 2022-01-01 | Unleashing the potential of DNA and RNA based therapies using AI · whitelabgx.com | still up |
| 2019-06-01 | Arpeggio Bio develops drugs targeting transcription factors using AI… · arpeggiobio.com | still up |
| 2021-01-01 | Discovering bispecific antibody drug-conjugates (BsADC) against cancer · valinktx.com | still up |
| 2020-01-01 | Using CRISPR to find treatments for cancer and inflammation · algenbio.com | still up |
| 2025-01-01 | AI drug discovery platform for neurotherapeutics · exintherapeutics.com | still up |
| 2021-06-01 | Programmable biology company for psychoactive effect design · mindstate.design | still up |
| 2023-01-01 | Developing long-lasting drug formulations 50% faster · persist-ai.com | still up |
| 2024-06-01 | YCACX Next-generation biocides for sustainable agriculture at scale · acxtherapeutics.com | still up |
| 2026-01-01 | YCOrigin AI and Data for Cancer Therapeutics · origin.bio | still up |
| 2025-09-01 | A Foundation Model for Microbial Communities. · anto.bio | still up |
| 2022-06-01 | YCQuinn Your biopharma team, from molecule design to portfolio strategy · quinnbio.com | still up |
| 2026-06-01 | AI-native materials discovery powered by unpublished experimental data · 83sciences.ai | still up |
| 2025-09-01 | YCExonic Exonic is an AI-native cell and gene therapeutics company. · exonic.ai | still up |
| 2026-06-01 | YCGamgee Curing cancer. Starting with dogs. · gamgee.io | still up |
| 2026-01-01 | Multimodal foundation models to predict uncollected patient biology · strandai.com | still up |
| 2023-01-01 | AI Powered Product Discovery · rubberduckylabs.io | gone |
| 2026-01-01 | The first AI-powered uranium discovery company · terranox.ai | still up |
| 2019-06-01 | AI platform accelerating therapies for rare & inflammatory diseases. · gen1e.com | still up |
| 2015-01-01 | AI-powered technology enabler and digital transformer of American… · grubmarket.com | still up |
| 2015-06-01 | YCIronclad AI-powered contract management · ironcladapp.com | still up |
| 2014-01-01 | YCUnbabel AI-powered Language Operations platform · unbabel.com | acquired |
| 2015-01-01 | YCTempo Live home fitness training powered by computer vision. · tempo.fit | still up |
| 2017-06-01 | AI-powered checkout for retail. · standard.ai | still up |
How this compares
Older launches have had longer to die, so this slope is expected. A year that broke it would mean something is wrong with the checking.
Matched on whole words in the title and description, so a launch can fall into two categories and plenty fall into none.
The register re-probes every domain it holds. Some that answered last month stop answering. We send that list — what went quiet, and what it was — once a month. Nothing else.
How this was made. Show HN entries are every post from 2021 to 2023 with at least five points that linked to its own domain; code hosts and free hosting are excluded, because a repository outlives the effort behind it. Product Hunt entries needed 100 votes — a far higher bar, so they are the promoted top slice rather than a like-for-like sample. Both are judged by asking the domain whether it still answers: gone means it no longer resolves, refuses the connection, serves a parking page, or says plainly that it shut down. An HTTP error is not counted as gone — a server answering 404 is one somebody still pays for, and an audit of 25 gone-calls found two such sites alive with only a moved homepage. Y Combinator entries use the status YC publishes itself, which is why only those can say acquired. Squatted domains — a lapsed name now serving somebody else's site — are not detected, so these figures run slightly low.