You asked about AI-powered Drug Discovery
567 people built something like it. 567 are gone.
That is 100% of the ones whose fate we could settle, against 23% across the whole register. Half of the gone ones were last seen within 20 months of launching.
| Launched | What it was | Today |
|---|---|---|
| 2018-01-01 | Engineering next-generation, brain-penetrant cancer therapies. · reverielabs.com | gone |
| 2019-01-01 | We solve drug resistance for cancer · resistance.bio | gone |
| 2010-06-01 | YCTeevox Teevox · teevox.com | gone |
| 2023-01-01 | AI for drug formulation · lavo.ai | gone |
| 2023-01-01 | AI Powered Product Discovery · rubberduckylabs.io | gone |
| 2022-10-03 | exactbuyer.com | gone |
| 2022-01-31 | ideas-generator.com | gone |
| 2021-09-03 | examples.jina.ai | gone |
| 2022-12-04 | remarkai.in | gone |
| 2015-06-01 | ROSS is an AI-powered legal research platform that can read and… · rossintelligence.com | gone |
| 2023-08-08 | allclues.ai | gone |
| 2023-09-25 | octomind.dev | gone |
| 2023-05-09 | flippit.ai | gone |
| 2019-01-01 | AI-powered corporate learning for accelerated employee growth & skill… · tailor-ed.com | gone |
| 2016-06-01 | An AI-powered digital grocer that delivers in under 60 mins. · farmsteadapp.com | gone |
| 2022-01-01 | YCPeakPath Smartwatch powered coaching to improve teams sustainable performance · peakpath.com | gone |
| 2023-02-07 | dbsensei.com | gone |
| 2023-05-21 | planitearth.travel | gone |
| 2020-01-01 | We’re creating programmable therapies · felixbt.com | gone |
| 2023-06-29 | clevis.volca.io | gone |
| 2021-05-01 | namebatao.com | gone |
| 2021-01-01 | Discover drugs that control how much cells "squeeze" to treat disease · forcytebio.com | gone |
| 2022-01-01 | YCCoffeeAI Instant, hyper-personalized, AI-powered outreach messages · get-coffee.ai | gone |
| 2022-12-14 | aispiritanimal.com | gone |
| 2023-02-14 | vday.galerie.ai | gone |
| 2021-06-01 | wordblot.ai | gone |
| 2022-06-01 | API for Retrieval Augmented Generation · superpowered.ai | gone |
| 2019-01-01 | YCHypnos AI-powered sleep coach learns and optimizes your sleep · hypnos.ai | gone |
| 2022-06-01 | YCStellar AI-powered business goals · stellarapp.io | gone |
| 2022-01-01 | Bioinformatics pipelines in the cloud · flowdeploy.com | gone |
| 2023-01-01 | AI-powered customer support automation for fast-growing companies · opensight.ai | gone |
| 2019-06-01 | EncepHeal develops medications to treat substance abuse, starting… · encepheal.com | gone |
| 2021-01-01 | YCCodeball AI-Powered Code Review · codeball.ai | gone |
| 2024-01-01 | The world's best presentation editor, powered by AI. · thorntale.com | gone |
| 2023-01-01 | AI-powered data extraction engine · indexical.dev | gone |
| 2024-01-01 | Your team’s AI powered communication tool · atpatchwork.com | gone |
| 2017-06-01 | First agentic AI-powered community for 1 billion people with criminal… · commissary.club | gone |
| 2022-06-01 | AI powered web & mobile automation · dev-tools.ai | gone |
| 2020-06-01 | Accelerating protein engineering. · trident.bio | gone |
| 2022-08-23 | pornpen.ai | gone |
| 2022-11-30 | thegist.ai | gone |
| 2022-05-23 | getnora.page | gone |
| 2019-01-01 | The everything store for restaurants in LATAM. · frubana.com | gone |
| 2023-06-25 | dialup.net | gone |
| 2022-01-20 | truesource.io | gone |
| 2022-07-07 | router.via.exchange | gone |
| 2022-12-20 | paidlink.to | gone |
| 2022-01-19 | dakiya.xyz | gone |
| 2022-02-17 | shell.how | gone |
| 2022-10-10 | playlists.dags.dev | gone |
| 2022-07-12 | airgram.io | gone |
| 2022-01-31 | magistrate.khanna.law | gone |
| 2022-02-02 | devtoolsfortailwind.com | gone |
| 2022-07-30 | saasnapkin.com | gone |
| 2022-06-15 | humit.app | gone |
| 2022-04-26 | sigmamail.ai | gone |
| 2023-02-22 | jotte.ai | gone |
| 2018-06-01 | YCKobo360 Africa's leading supply chain technology platform. · kobo360.com | gone |
| 2022-05-17 | blendsocial.io | gone |
| 2022-04-22 | sonero.ai | gone |
How this compares
Y Combinator reports its own outcomes, including acquisitions. The other two are judged by asking the domain, so they are not measured the same way and are never averaged together.
Older launches have had longer to die, so this slope is expected. A year that broke it would mean something is wrong with the checking.
The register re-probes every domain it holds. Some that answered last month stop answering. We send that list — what went quiet, and what it was — once a month. Nothing else.
How this was made. Show HN entries are every post from 2021 to 2023 with at least five points that linked to its own domain; code hosts and free hosting are excluded, because a repository outlives the effort behind it. Product Hunt entries needed 100 votes — a far higher bar, so they are the promoted top slice rather than a like-for-like sample. Both are judged by asking the domain whether it still answers: gone means it no longer resolves, refuses the connection, serves a parking page, or says plainly that it shut down. An HTTP error is not counted as gone — a server answering 404 is one somebody still pays for, and an audit of 25 gone-calls found two such sites alive with only a moved homepage. Y Combinator entries use the status YC publishes itself, which is why only those can say acquired. Squatted domains — a lapsed name now serving somebody else's site — are not detected, so these figures run slightly low.