You asked about Drug discovery
19 people built something like it. 0 are gone.
That is 0% of the ones whose fate we could settle, against 23% across the whole register.
| Launched | What it was | Today |
|---|---|---|
| 2021-06-01 | YCAdaptyv We're building fully automated labs for protein engineering · adaptyvbio.com | still up |
| 2021-06-01 | Using the immune system to cure disease · parallel.bio | still up |
| 2021-06-01 | Discovering drugs that target the DNA regulome · talus.bio | still up |
| 2021-01-01 | Discovering bispecific antibody drug-conjugates (BsADC) against cancer · valinktx.com | still up |
| 2021-06-01 | We make injections as easy as pushing a button! · pirouettepharma.com | still up |
| 2021-06-01 | Multi-targeted therapeutics to treat complex diseases · harmonicdiscovery.com | still up |
| 2021-06-01 | The foundation for the next era of biology · outputbio.com | still up |
| 2021-06-01 | Programmable biology company for psychoactive effect design · mindstate.design | still up |
| 2021-01-01 | Genetic Medicine with Small Molecules · serna.bio | still up |
| 2021-06-01 | Regulating the immune system to block cancer & autoimmune diseases · sfatherapeutics.com | still up |
| 2021-06-01 | The dynamic single-cell analysis company · cellchorus.com | still up |
| 2021-06-01 | Developing milk-inspired therapeutics for infectious diseases · matrubials.com | still up |
| 2021-09-03 | linklonk.com | still up |
| 2021-11-15 | selectstar.com | still up |
| 2021-01-01 | Take Care of Shitty Paperwork for Expensive Drugs · lamarhealth.com | still up |
| 2021-03-03 | secoda.co | still up |
| 2021-10-27 | listenbrainz.org | still up |
| 2021-12-24 | curatora.io | still up |
| 2021-01-01 | Creating a New Class of Drugs to Address Incurable Autoimmune Diseases · entelexo.com | still up |
How this compares
Y Combinator reports its own outcomes, including acquisitions. The other two are judged by asking the domain, so they are not measured the same way and are never averaged together.
The register re-probes every domain it holds. Some that answered last month stop answering. We send that list — what went quiet, and what it was — once a month. Nothing else.
How this was made. Show HN entries are every post from 2021 to 2023 with at least five points that linked to its own domain; code hosts and free hosting are excluded, because a repository outlives the effort behind it. Product Hunt entries needed 100 votes — a far higher bar, so they are the promoted top slice rather than a like-for-like sample. Both are judged by asking the domain whether it still answers: gone means it no longer resolves, refuses the connection, serves a parking page, or says plainly that it shut down. An HTTP error is not counted as gone — a server answering 404 is one somebody still pays for, and an audit of 25 gone-calls found two such sites alive with only a moved homepage. Y Combinator entries use the status YC publishes itself, which is why only those can say acquired. Squatted domains — a lapsed name now serving somebody else's site — are not detected, so these figures run slightly low.