You asked about AI-powered Drug Discovery
3,243 people built something like it. 0 are gone.
That is 0% of the ones whose fate we could settle, against 23% across the whole register.
| Launched | What it was | Today |
|---|---|---|
| 2015-01-01 | Artificial intelligence for drug discovery. · numerionlabs.ai | still up |
| 2020-01-01 | YCPostEra Medicinal Chemistry powered by Machine Learning · postera.ai | still up |
| 2016-01-01 | YCQvin Empowering women. Period. · qvin.com | still up |
| 2021-06-01 | YCAdaptyv We're building fully automated labs for protein engineering · adaptyvbio.com | still up |
| 2021-06-01 | Using the immune system to cure disease · parallel.bio | still up |
| 2024-01-01 | AI Inference Platform for Drug Discovery · tamarind.bio | still up |
| 2019-01-01 | YC1910 Multimodal AI Platform for Modality Agnostic Drug Discovery™ · 1910.ai | still up |
| 2018-01-01 | Computational antibody design · macromoltek.com | still up |
| 2023-01-01 | Generative AI for protein design · diffuse.bio | still up |
| 2021-06-01 | Multi-targeted therapeutics to treat complex diseases · harmonicdiscovery.com | still up |
| 2021-06-01 | The foundation for the next era of science · outputbio.com | still up |
| 2020-06-01 | We use AI to design antibodies for intractable diseases · nabla.bio | still up |
| 2018-01-01 | We are using the gut microbiome to end cancer. · persephonebiosciences.com | still up |
| 2020-01-01 | Altay develops disease-modifying therapies targeting transcription… · altaytherapeutics.com | still up |
| 2024-06-01 | Gen AI molecular simulations that reproduce wetlab results · angstrom-ai.com | still up |
| 2023-06-01 | YCNanograb Deliver genes to any cell with AI · nanograb.com | still up |
| 2021-06-01 | Regulating the immune system to block cancer & autoimmune diseases · sfatherapeutics.com | still up |
| 2025-09-01 | Biospecimen logistics & operations layer to accelerate drug dev · playhealth.com | still up |
| 2026-01-01 | YCOrigin AI and Data for Cancer Therapeutics · origin.bio | still up |
| 2025-06-01 | YCConvexia The world's first AI-maximalist pharma company · convexia.bio | still up |
| 2021-06-01 | The dynamic single-cell analysis company · cellchorus.com | still up |
| 2021-06-01 | Developing milk-inspired therapeutics for infectious diseases · matrubials.com | still up |
| 2019-06-01 | YCShiru Shiru leverages ML to create proteins to feed the world sustainably. · shiru.com | still up |
| 2022-01-01 | Growing micro-organs to find new drugs · rosebudbiosciences.com | still up |
| 2026-09-01 | Maximum information per experiment, minimum experiments per conclusion · halmoslabs.com | still up |
| 2026-06-01 | AI-native pharma company · atlasdiscovery.bio | still up |
| 2024-01-01 | YCGloGlo Curing and preventing type 1 diabetes · gloglo.com | still up |
| 2026-06-01 | YCWonderTx Extrapolative AI to unlock First-in-Class drugs · wondertx.ai | still up |
| 2024-06-01 | Making Next-Generation Antibiotics that Outpace Bacterial Evolution · evolverebiosciences.com | still up |
| 2025-06-01 | YCb12 Labs Making hard molecules for Pharma and Biotech · b12-labs.com | still up |
| 2020-01-01 | Menten AI designs peptide and protein therapeutics using quantum… · menten.ai | still up |
| 2018-06-01 | Synkrino's AI, SATIS is a powerful, unbiased discovery system for… · synkrino.bio | still up |
| 2022-06-01 | YCKeylika Redefining the Standard of Care for Iron Deficiency Anemia · keylika.com | still up |
| 2015-06-01 | We use human data and AI to develop better drugs faster. · vergegenomics.com | still up |
| 2022-01-01 | Unleash the potential of genomic medicine using AI · whitelabgx.com | still up |
| 2017-01-01 | Next-generation mRNA platform to solve cancer, COVID and climate. · helixnano.com | still up |
| 2019-06-01 | Arpeggio Bio develops drugs targeting transcription factors using AI… · arpeggiobio.com | still up |
| 2021-01-01 | Discovering bispecific antibody drug-conjugates (BsADC) against cancer · valinktx.com | still up |
| 2020-01-01 | Using CRISPR to find treatments for cancer and inflammation · algenbio.com | still up |
| 2025-01-01 | AI drug discovery platform for neurotherapeutics · exintherapeutics.com | still up |
| 2021-06-01 | Programmable biology company for psychoactive effect design · mindstate.design | still up |
| 2023-01-01 | Developing long-lasting drug formulations 50% faster · persist-ai.com | still up |
| 2023-01-01 | Empowering every doctor and every patient to participate in research · novel.care | still up |
| 2025-09-01 | A Foundation Model for Microbial Communities. · anto.bio | still up |
| 2022-06-01 | YCQuinn Your biopharma team, from molecule design to portfolio strategy · quinnbio.com | still up |
| 2024-06-01 | YCACX Next-generation biocides for sustainable agriculture at scale · acxtherapeutics.com | still up |
| 2016-06-01 | YCSynvivia Synvivia applies chemical control over cell behavior · synvivia.com | still up |
| 2025-09-01 | YCExonic Exonic is an AI-native cell and gene therapeutics company. · exonic.ai | still up |
| 2026-06-01 | AI-native materials discovery powered by unpublished experimental data · 83sciences.ai | still up |
| 2026-01-01 | The first AI-powered uranium discovery company · terranox.ai | still up |
| 2026-06-01 | YCGamgee Curing cancer. Starting with dogs. · gamgee.io | still up |
| 2026-01-01 | Multimodal foundation models to predict uncollected patient biology · strandai.com | still up |
| 2019-06-01 | AI platform accelerating therapies for rare & inflammatory diseases. · gen1e.com | still up |
| 2026-09-01 | The full-stack AI CRO for drug discovery. · nxtcure.com | still up |
| 2015-01-01 | AI-powered technology enabler and digital transformer of American… · grubmarket.com | still up |
| 2022-06-15 | softr.io | still up |
| 2015-06-01 | YCIronclad AI-powered contract management · ironcladapp.com | still up |
| 2022-05-05 | supermeme.ai | still up |
| 2022-10-17 | lex.page | still up |
| 2023-10-19 | autotab.com | still up |
How this compares
Y Combinator reports its own outcomes, including acquisitions. The other two are judged by asking the domain, so they are not measured the same way and are never averaged together.
Older launches have had longer to die, so this slope is expected. A year that broke it would mean something is wrong with the checking.
Matched on whole words in the title and description, so a launch can fall into two categories and plenty fall into none.
The register re-probes every domain it holds. Some that answered last month stop answering. We send that list — what went quiet, and what it was — once a month. Nothing else.
How this was made. Show HN entries are every post from 2021 to 2023 with at least five points that linked to its own domain; code hosts and free hosting are excluded, because a repository outlives the effort behind it. Product Hunt entries needed 100 votes — a far higher bar, so they are the promoted top slice rather than a like-for-like sample. Both are judged by asking the domain whether it still answers: gone means it no longer resolves, refuses the connection, serves a parking page, or says plainly that it shut down. An HTTP error is not counted as gone — a server answering 404 is one somebody still pays for, and an audit of 25 gone-calls found two such sites alive with only a moved homepage. Y Combinator entries use the status YC publishes itself, which is why only those can say acquired. Squatted domains — a lapsed name now serving somebody else's site — are not detected, so these figures run slightly low.