You asked about AI-powered Drug Discovery
Nobody in the register described anything this way.
| Launched | What it was | Today |
|---|---|---|
| 2020-06-01 | Combining 3D cell culture & AI to translate drugs to clinical success · knownmed.com | acquired |
| 2021-01-01 | YCPipeBio PipeBio is a SaaS bioinformatics platform to develop antibody drugs. · pipebio.com | acquired |
| 2014-01-01 | YCUnbabel AI-powered Language Operations platform · unbabel.com | acquired |
| 2015-01-01 | Personalized drug discovery for blood cancer. · notablelabs.com | acquired |
| 2020-06-01 | AI-powered user assistance platform · command.ai | acquired |
| 2020-01-01 | YCPowerX AI powered sensors that save energy, water and emissions · powerx.co | acquired |
| 2016-01-01 | YCCaper Plug-and-play cashier-less retail powered by computer vision and AI · caper.ai | acquired |
| 2018-01-01 | YCEdwin Edwin is virtual English tutor - an AI-powered service for learning… · edwin.ai | acquired |
| 2018-06-01 | YCPhiar We are developing a revolutionary AI-powered augmented reality… · phiar.net | acquired |
| 2022-01-01 | Potent, durable, and redosable non-viral genetic medicines · engagebio.com | acquired |
| 2021-06-01 | AI-Powered Business Development for Scientific Organizations · firstignite.com | acquired |
| 2019-01-01 | YCWindsor AI Powered Personalized Videos · windsor.io | acquired |
| 2018-06-01 | New clinical tests for managing autoimmune treatments. · coralgenomics.com | acquired |
| 2023-06-01 | The AI-powered risk decision platform · trycatamaran.com | acquired |
| 2023-01-01 | YCOfOne AI-powered order taker for restaurant drive-thrus · of.one | acquired |
| 2023-06-01 | YCWatto AI AI-powered McKinsey-quality reports in seconds · watto.ai | acquired |
| 2015-06-01 | Patient-derived 3D tissue reconstruction models for preclinical… · zpredicta.com | acquired |
| 2020-06-01 | We break viruses · pardesbio.com | acquired |
| 2021-06-01 | YCMentum AI-Powered Assistant for Procurement and Strategic Sourcing · getmentum.com | acquired |
| 2020-01-01 | The better way to run single cell genomics · dropprintgen.com | acquired |
| 2020-01-01 | App offering AI powered workout plans with anytime access to coaches · fitnessai.com | acquired |
| 2009-01-01 | YCAirbnb Book accommodations around the world. · airbnb.com | acquired |
| 2014-01-01 | YCCruise Self-driving cars. · getcruise.com | acquired |
| 2007-01-01 | YCTwitch A global community creating the future of live entertainment. · twitch.com | acquired |
| 2016-06-01 | YCMeesho Democratizing internet commerce for everyone in India · meesho.com | acquired |
| 2011-01-01 | Customer loyalty and payments platform for small businesses. · fivestars.com | acquired |
| 2013-01-01 | IMPORTANT: The original YC founders are no longer involved with this… · teespring.com | acquired |
| 2010-06-01 | YCPresto Digital meets physical for big chain restaurants · presto.com | acquired |
| 2022-01-01 | YCRider Modern parcel delivery for online sellers in Pakistan. · withrider.com | acquired |
| 2017-01-01 | YCUpKeep Mobile-first software for maintenance teams. · upkeep.com | acquired |
| 2012-01-01 | Car Repairs, Reinvented:a. Mechanic comes to your home or work to fix… · yourmechanic.com | acquired |
| 2018-01-01 | Digitize and Automate Complex Care Workflows · memorahealth.com | acquired |
| 2011-01-01 | Pay what you want for awesome games and other content while giving to… · humble.com | acquired |
| 2019-01-01 | YCHatch The AI CSR Platform · usehatch.ai | acquired |
| 2014-01-01 | YCGobble Daily meal delivery, personalized to your tastes. · gobble.com | acquired |
| 2021-06-01 | YCMailmodo No-code email marketing platform to send forms & widgets within emails · mailmodo.com | acquired |
| 2015-01-01 | YCLumi Packaging for online brands. · lumi.com | acquired |
| 2019-01-01 | YCForage Online job simulations for companies to train, and then hire, students · theforage.com | acquired |
| 2023-01-01 | YCStackAI The Enterprise AI Transformation Platform · stackai.com | acquired |
| 2016-06-01 | YCBurrow A design brand creating innovative, award winning furniture. · burrow.com | acquired |
| 2018-06-01 | YCRegology AI Agents for Regulatory Compliance · regology.com | acquired |
| 2014-06-01 | The system of record for government affairs. · govpredict.com | acquired |
| 2020-06-01 | YCWarmly, [Acquired by HubSpot in 2026] Autonomous sales platform to auto-email… · warmly.ai | acquired |
| 2022-01-01 | YCSkyLink Travel Management Meets AI · tryskylink.com | acquired |
| 2011-01-01 | YCMailgun Email API service. · mailgun.net | acquired |
| 2012-06-01 | YCSoylent Soylent is a simple, nutritious, and affordable food that possesses… · soylent.com | acquired |
| 2010-01-01 | the best loyalty and retention marketing partner for CMOs. · 500friends.com | acquired |
| 2012-01-01 | YCTilt Mobile crowdfunding: The easiest way to collect, fundraise, and sell… · tilt.com | acquired |
| 2015-01-01 | Bluesmart makes smart luggage powered by an app to empower people to… · bluesmart.com | acquired |
| 2019-06-01 | YCVendr The AI negotiation agent to help you save money on SaaS. · vendr.com | acquired |
| 2019-06-01 | YCCuboh We help restaurants manage their online orders. · cuboh.com | acquired |
| 2015-01-01 | Paperspace is a cloud platform for building and scaling AI… · paperspace.com | acquired |
| 2019-06-01 | On demand fuel delivery service in India · mypetrolpump.com | acquired |
| 2018-06-01 | Transforms how grocery stores buy highly perishable foods. · shelfengine.com | acquired |
| 2020-01-01 | Run machine learning models in the cloud · replicate.com | acquired |
| 2014-06-01 | YCImpraise Enable managers to create an effective work environment for their team · impraise.com | acquired |
| 2023-01-01 | YCPlayAI Our mission is to make Voice AI accessible and useful to all. · play.ai | acquired |
| 2014-01-01 | YCTheorem The mission of Theorem is to make credit safe and available. We use… · theoremlp.com | acquired |
| 2021-01-01 | YCFinley Streamline your debt capital raise and management · finleycms.com | acquired |
| 2017-01-01 | YCShipamax Simple, end-to-end automation for logistics orgs · shipamax.com | acquired |
How this compares
The register re-probes every domain it holds. Some that answered last month stop answering. We send that list — what went quiet, and what it was — once a month. Nothing else.
How this was made. Show HN entries are every post from 2021 to 2023 with at least five points that linked to its own domain; code hosts and free hosting are excluded, because a repository outlives the effort behind it. Product Hunt entries needed 100 votes — a far higher bar, so they are the promoted top slice rather than a like-for-like sample. Both are judged by asking the domain whether it still answers: gone means it no longer resolves, refuses the connection, serves a parking page, or says plainly that it shut down. An HTTP error is not counted as gone — a server answering 404 is one somebody still pays for, and an audit of 25 gone-calls found two such sites alive with only a moved homepage. Y Combinator entries use the status YC publishes itself, which is why only those can say acquired. Squatted domains — a lapsed name now serving somebody else's site — are not detected, so these figures run slightly low.