You asked about AI-powered Drug Discovery
26 people built something like it. 2 are gone.
That is 8% of the ones whose fate we could settle, against 23% across the whole register. 1 were acquired.
| Launched | What it was | Today |
|---|---|---|
| 2022-06-01 | YCJuicebox AI-powered talent sourcing for recruiters · juicebox.ai | still up |
| 2023-06-01 | YCCercli AI powered HR and Recruitment for people teams · cercli.com | still up |
| 2025-01-01 | AI hiring platform powered by expert recruiters · contrario.ai | still up |
| 2023-06-01 | YCBolto AI Powered All-In-One Payroll, HR + Recruiting · bolto.com | still up |
| 2022-01-01 | YCLumina AI+human powered automation on job-community platform with 1.5M… · lumibot.com | still up |
| 2017-06-01 | First agentic AI-powered community for 1 billion people with criminal… · commissary.club | gone |
| 2015-06-01 | YCFountain High volume hiring made simple · fountain.com | still up |
| 2021-06-01 | YCStepful Online Training for Healthcare Jobs · stepful.com | still up |
| 2019-06-01 | YCVahan AI recruiter for India's massive blue-collar workforce · vahan.ai | still up |
| 2019-01-01 | YCForage Online job simulations for companies to train, and then hire, students · theforage.com | acquired |
| 2025-01-01 | YCSpott AI-native ATS/CRM for recruiting firms · spott.io | still up |
| 2019-01-01 | YCLanded Generative AI for frontline worker hiring · gotlanded.com | still up |
| 2021-01-01 | YCWeekday AI recruiter that runs outbound sourcing campaigns to find top talent · weekday.works | still up |
| 2022-01-01 | AI solution that streamlines candidate screening and recruitment · talentropy.ai | still up |
| 2024-01-01 | YCAlex Alex is the AI recruiter for hiring great people. · alex.com | still up |
| 2023-06-01 | AI enabled marketplace matching trucks with jobs · fleetworks.ai | still up |
| 2023-01-01 | Discover new opportunities (jobs, deals, investors) · alphawatch.ai | still up |
| 2023-06-01 | YCFiber AI The freshest data APIs for AI sales, recruiting, & growth products · fiber.ai | still up |
| 2023-06-01 | YCSerra Your 24/7 AI Recruiter · serra.io | still up |
| 2025-09-01 | YCSorce Tinder for jobs · sorce.jobs | still up |
| 2020-01-01 | YCEdlyft Helps enterprises train college CS students on essential job skills · edlyft.com | gone |
| 2026-01-01 | The AI-native Recruiting OS · perfectly.so | still up |
| 2026-06-01 | Robots that learn on the job · shiraz.ai | still up |
| 2026-06-01 | YCTsenta AI career agent that finds matching jobs & applies on your behalf · tsenta.com | still up |
| 2025-01-01 | YCOvlo Founder led hiring for London startups · ovlo.ai | still up |
| 2026-01-01 | YCVela AI Recruiting Coordinator for Executive Search · tryvela.ai | still up |
How this compares
Matched on whole words in the title and description, so a launch can fall into two categories and plenty fall into none.
The register re-probes every domain it holds. Some that answered last month stop answering. We send that list — what went quiet, and what it was — once a month. Nothing else.
How this was made. Show HN entries are every post from 2021 to 2023 with at least five points that linked to its own domain; code hosts and free hosting are excluded, because a repository outlives the effort behind it. Product Hunt entries needed 100 votes — a far higher bar, so they are the promoted top slice rather than a like-for-like sample. Both are judged by asking the domain whether it still answers: gone means it no longer resolves, refuses the connection, serves a parking page, or says plainly that it shut down. An HTTP error is not counted as gone — a server answering 404 is one somebody still pays for, and an audit of 25 gone-calls found two such sites alive with only a moved homepage. Y Combinator entries use the status YC publishes itself, which is why only those can say acquired. Squatted domains — a lapsed name now serving somebody else's site — are not detected, so these figures run slightly low.