You asked about Genetic Engineering
220 people built something like it. 18 are gone.
That is 9% of the ones whose fate we could settle, against 23% across the whole register. 16 were acquired.
| Launched | What it was | Today |
|---|---|---|
| 2016-06-01 | YCScale AI Data-centric infrastructure to accelerate the development of AI · scale.com | still up |
| 2016-01-01 | YCSendbird The AI agent that doesn’t just support, it delights. · sendbird.com | still up |
| 2016-01-01 | AI + Robotics for the Built World · geckorobotics.com | still up |
| 2019-06-01 | YCCoLab Human and AI design review for hardware · colabsoftware.com | still up |
| 2016-01-01 | YCDeepgram Building foundational AI for speech transcription and understanding. · deepgram.com | still up |
| 2020-01-01 | YCAirbyte Context layer for production-grade AI agents · airbyte.com | still up |
| 2022-01-01 | AI-native operating system for home service businesses · broccoli.com | still up |
| 2019-01-01 | Superb AI provides end-to-end computer vision MLOps platform · superb-ai.com | still up |
| 2021-06-01 | YCVerihubs AI-powered Deepfake Detection · verihubs.com | still up |
| 2021-01-01 | YCMindee AI Document Understanding API · mindee.com | still up |
| 2021-01-01 | YCVapi Voice AI for developers. · vapi.ai | still up |
| 2020-06-01 | YCLuminai Luminai is the AI platform for Health System Operations. · luminai.com | still up |
| 2024-06-01 | AI Agents for collections · domu.ai | still up |
| 2015-01-01 | Paperspace is a cloud platform for building and scaling AI… · paperspace.com | acquired |
| 2023-01-01 | YCPirros AI Platform for Architects and Engineers · pirros.com | still up |
| 2018-01-01 | YCVeriff AI-powered identity verification solution for fraud prevention. · veriff.com | still up |
| 2022-01-01 | Compliant-Ready AI for the Enterprise · dynamo.ai | still up |
| 2022-01-01 | YCBotCity Observability and Governance for AI-Generated Python scripts. · botcity.dev | still up |
| 2022-01-01 | YCLanceDB Open-source, serverless vectordb for production-scale generative AI · lancedb.com | still up |
| 2024-01-01 | YCGreptile AI code review agent with complete context of your codebase · greptile.com | still up |
| 2020-06-01 | AI-powered user assistance platform · command.ai | acquired |
| 2024-01-01 | Accelerate Medication Access with AI · runtrellis.com | still up |
| 2021-01-01 | YCauthzed Authorization Infrastructure securing AI at OpenAI, Zoom, & more · authzed.com | still up |
| 2020-06-01 | YCDatafold Automating manual and repetitive data engineering tasks with AI · datafold.com | still up |
| 2025-01-01 | YCMastra The Javascript framework for building AI agents, from the Gatsby devs · mastra.ai | still up |
| 2023-06-01 | YCGiga AI Support Agent for Enterprises. · giga.ai | still up |
| 2021-06-01 | YCSecoda Secoda is the AI layer for your Analytics · secoda.co | still up |
| 2024-01-01 | Autonomous offensive and defensive cybersecurity platform · codeant.ai | still up |
| 2021-06-01 | YCMach9 AI CAD Software for Civil Engineering · mach9.ai | still up |
| 2021-06-01 | The fastest way to ship airtight AI · openlayer.com | still up |
| 2015-06-01 | AI-assisted electronics design · snapmagic.com | still up |
| 2020-01-01 | YCNextmv A DecisionOps platform that accelerates optimization AI teams · nextmv.io | acquired |
| 2024-01-01 | YCOpen Enterprise AI customer support · open.cx | still up |
| 2023-06-01 | YCTiptap The open-source document editor for humans and AI agents. · tiptap.dev | still up |
| 2023-01-01 | YCLangfuse Open source LLM engineering platform · langfuse.com | acquired |
| 2021-06-01 | YCAbstra Automate finance operations with Python and AI · abstra.io | still up |
| 2023-01-01 | YCInkeep Build AI Agent teammates and automations in code or no-code · inkeep.com | still up |
| 2024-09-01 | YCCekura Voice AI and Chat AI agents: Testing and Observability · cekura.ai | still up |
| 2025-06-01 | YCF2 The AI platform for private markets investors · f2.ai | still up |
| 2024-06-01 | YCEntangl Find & resolve issues in data center engineering & operations using AI · entangl.com | still up |
| 2021-06-01 | Affogato AI — Your Agent for instant TikToks, Reels, and ads. · affogato.ai | still up |
| 2021-06-01 | AI native mobile testing. · mobileboost.io | still up |
| 2022-06-01 | YCIntuned Code-first scrapers and RPAs — built and maintained by AI · intunedhq.com | still up |
| 2020-06-01 | Humanloop is the LLM evals platform for enterprises. · humanloop.com | acquired |
| 2024-01-01 | YCDraftaid Go from 3D models to CAD drawings using AI · draftaid.io | still up |
| 2025-01-01 | YCWeave AI to understand and then route engineering work · weaveos.com | still up |
| 2021-01-01 | YCWaydev Engineering intelligence for AI transformation · waydev.co | still up |
| 2015-01-01 | YCTara AI Meet Tara AI, your new engineering efficiency co-pilot. · tara.ai | still up |
| 2024-06-01 | YCZeit AI The autonomous data engineer for the mid-market · zeit-ai.com | still up |
| 2014-01-01 | YCWit.ai Natural Language for Developers --Wit is an API that makes it easy… · wit.ai | acquired |
| 2022-06-01 | YCLamin Open data platform for traceable, multimodal AI · lamin.ai | still up |
| 2024-06-01 | Automate circuit board design using AI · diode.computer | still up |
| 2023-06-01 | AI for Government Contracting. · sweetspot.so | still up |
| 2025-09-01 | YCMOVEdot AI Agents for Hardware Engineering · movedot.ai | still up |
| 2024-06-01 | YCCoval Simulation & Evaluation that scales voice and chat AI agents · coval.dev | still up |
| 2022-06-01 | Open-source, AI-first and no-code business automation tool · activepieces.com | still up |
| 2021-06-01 | Plan and review AI generated code · vibekanban.com | still up |
| 2023-01-01 | Go from idea to production with AI. · magicpatterns.com | still up |
| 2025-06-01 | YCWafer AI that makes AI fast · wafer.ai | still up |
| 2022-01-01 | AI-driven HVAC control system for improved energy performance · axross.co | still up |
How this compares
Older launches have had longer to die, so this slope is expected. A year that broke it would mean something is wrong with the checking.
The register re-probes every domain it holds. Some that answered last month stop answering. We send that list — what went quiet, and what it was — once a month. Nothing else.
How this was made. Show HN entries are every post from 2021 to 2023 with at least five points that linked to its own domain; code hosts and free hosting are excluded, because a repository outlives the effort behind it. Product Hunt entries needed 100 votes — a far higher bar, so they are the promoted top slice rather than a like-for-like sample. Both are judged by asking the domain whether it still answers: gone means it no longer resolves, refuses the connection, serves a parking page, or says plainly that it shut down. An HTTP error is not counted as gone — a server answering 404 is one somebody still pays for, and an audit of 25 gone-calls found two such sites alive with only a moved homepage. Y Combinator entries use the status YC publishes itself, which is why only those can say acquired. Squatted domains — a lapsed name now serving somebody else's site — are not detected, so these figures run slightly low.