You asked about Gene Therapy
43 people built something like it. 4 are gone.
That is 10% of the ones whose fate we could settle, against 23% across the whole register. 2 were acquired.
| Launched | What it was | Today |
|---|---|---|
| 2024-01-01 | YCLegora The AI workspace for lawyers · legora.com | still up |
| 2024-09-01 | AI tutors for students. · generallearning.com | still up |
| 2024-01-01 | YCOpen Enterprise AI customer support · open.cx | still up |
| 2024-06-01 | Automate security and privacy reviews · clearly-ai.com | still up |
| 2024-06-01 | YCUsul AI Platform for Winning Defense & Government Contracts · usul.com | still up |
| 2024-06-01 | YCMem0 The Memory layer for AI Agents · mem0.ai | still up |
| 2024-01-01 | YCROE AI for risk and compliance · getroe.ai | still up |
| 2024-01-01 | YCSenso Control what AI says about you · senso.ai | still up |
| 2024-06-01 | Open-Source Reinforcement Learning (RL) & Fine-tuning for LLMs. · unsloth.ai | still up |
| 2024-06-01 | YCDataleap AI Employees for the Enterprise · dataleap.ai | still up |
| 2024-06-01 | YCKenley AI Agents for Advisory & Financial Services. · kenley.ai | still up |
| 2024-09-01 | YCx1 AI app builder for creating and launching iPhone apps · x1.new | still up |
| 2024-01-01 | YCMarblism AI Employees who love overtime · marblism.com | still up |
| 2024-01-01 | YCMathos Ultimate AI Math Problem Solver to Revolutionize Personalized Learning · info.mathos.ai | still up |
| 2024-06-01 | AI Report Generation for Engineering & Environmental Review · schemeflow.com | still up |
| 2024-01-01 | YCTusk AI agent that generates unit and integration tests · usetusk.ai | acquired |
| 2024-06-01 | YCRemade AI-native canvas for creative workflows. · remade.ai | acquired |
| 2024-06-01 | YCcamfer Building the world’s first AI mechanical engineer. · camfer.dev | gone |
| 2024-01-01 | The AI Labor Company · brainbaselabs.com | still up |
| 2024-01-01 | YCDuckie Build AI Support Agents in Minutes · duckie.ai | still up |
| 2024-06-01 | Java-native multi-agentic AI operating system for enterprise · redouble.ai | still up |
| 2024-06-01 | YCRentFlow The AI infrastructure for cash-flow-aligned business rent · therentflow.com | still up |
| 2024-06-01 | YCMagiCode A Reliable AI Frontend Engineer · magicode.ai | still up |
| 2024-01-01 | AI media creation platform for creators and developers · magichour.ai | still up |
| 2024-01-01 | YCAedilic Open-Source AI-generated image/deepfake detection · nonescape.com | gone |
| 2024-01-01 | YCOneGrep AI Agent for DevOps Workflow Automation · onegrep.dev | still up |
| 2024-09-01 | YCMelder AI formulas and document support for Microsoft Excel · melder.io | still up |
| 2024-06-01 | YCKura AI New State of the Art for Browser Agents · trykura.com | still up |
| 2024-01-01 | AI Therapy for OCD · themangohealth.com | gone |
| 2024-06-01 | ideate.xyz is an AI-powered 3D art suite on the web · ideate.xyz | still up |
| 2024-09-01 | Scaling Genomic AI for Embryo Selection · reticular.com | still up |
| 2024-01-01 | YCPenciled AI front office assistant for physical therapy · penciled.com | still up |
| 2024-01-01 | YCAdapted AI physical therapy for athletes · adapted.app | still up |
| 2024-09-01 | AI agents to automate corporate transactions · pearsonlabs.ai | still up |
| 2024-01-01 | GenAI Interactive story. Creator write fictions 10x faster. · storioai.com | still up |
| 2024-06-01 | YCOpslane Verify AI-generated code before you ship it · opslane.com | still up |
| 2024-01-01 | Personalized prevention using genetics and AI · haplotypelabs.com | still up |
| 2024-01-01 | YCLumona AI-enabled search engine featuring insights from social media. · lumona.ai | gone |
| 2024-09-01 | YCISSEN AI realtime voice companion for language learning · issen.com | still up |
| 2024-06-01 | YCZuni AI agents for high-value professional work · zuni.app | still up |
| 2024-01-01 | YCKabilah Agentic AI for Nursing Workflows · kabilah.com | still up |
| 2024-01-01 | LLM Security and Compliance · promptarmor.com | still up |
| 2024-06-01 | YCEmergent AI app builder that turns your ideas into monetizable software. · emergent.sh | still up |
How this compares
The register re-probes every domain it holds. Some that answered last month stop answering. We send that list — what went quiet, and what it was — once a month. Nothing else.
How this was made. Show HN entries are every post from 2021 to 2023 with at least five points that linked to its own domain; code hosts and free hosting are excluded, because a repository outlives the effort behind it. Product Hunt entries needed 100 votes — a far higher bar, so they are the promoted top slice rather than a like-for-like sample. Both are judged by asking the domain whether it still answers: gone means it no longer resolves, refuses the connection, serves a parking page, or says plainly that it shut down. An HTTP error is not counted as gone — a server answering 404 is one somebody still pays for, and an audit of 25 gone-calls found two such sites alive with only a moved homepage. Y Combinator entries use the status YC publishes itself, which is why only those can say acquired. Squatted domains — a lapsed name now serving somebody else's site — are not detected, so these figures run slightly low.