You asked about AI-powered Drug Discovery
146 people built something like it. 25 are gone.
That is 18% of the ones whose fate we could settle, against 23% across the whole register. 10 were acquired.
| Launched | What it was | Today |
|---|---|---|
| 2021-01-03 | headlime.com | still up |
| 2021-06-01 | YCVerihubs AI-powered Deepfake Detection · verihubs.com | still up |
| 2021-01-01 | YCHumaans AI-Powered HRIS for high performing teams · humaans.io | still up |
| 2021-09-03 | examples.jina.ai | gone |
| 2021-01-01 | AI-powered customer service for startups · cloudhumans.com | still up |
| 2021-01-01 | YCMoichor AI Powered Animal Diagnostics · moichor.com | still up |
| 2021-01-01 | Generative AI powered Shopify for home service professionals · toplinepro.com | still up |
| 2021-02-04 | evertrove.co | unverified |
| 2021-01-01 | AI-powered Compliance Platform for PCI 4, CCPA, HIPAA, CIPA, 50+ laws · feroot.com | still up |
| 2021-01-01 | YCSpokn AI-powered video platform for Internal Comms and HR teams · getspokn.com | still up |
| 2021-06-01 | YCEpsilon3 AI-Powered ERP, MES, and Test Software for Complex Operations · epsilon3.io | still up |
| 2021-06-01 | YCidemeum AI-powered Application Control · idemeum.com | still up |
| 2021-06-01 | AI-Powered Business Development for Scientific Organizations · firstignite.com | acquired |
| 2021-01-01 | Cut your writing time by 40% with AI-powered autocomplete · compose.ai | still up |
| 2021-06-01 | wordblot.ai | gone |
| 2021-12-15 | explaincode.app | still up |
| 2021-06-01 | AI-powered equity research software · hudson-labs.com | still up |
| 2021-05-01 | namebatao.com | gone |
| 2021-06-24 | reviewr.ai | still up |
| 2021-07-14 | booklyn.co | unverified |
| 2021-06-01 | The complete production quality platform. AI-powered E2E testing,… · artillery.io | still up |
| 2021-01-01 | YCCodeball AI-Powered Code Review · codeball.ai | gone |
| 2021-06-01 | YCMentum AI-Powered Assistant for Procurement and Strategic Sourcing · getmentum.com | acquired |
| 2021-01-01 | YCTractian Physical AI for asset-heavy industries · tractian.com | still up |
| 2021-01-01 | YCCyble Cyble - World’s First Intelligence-Driven, AI-Native Security… · cyble.com | still up |
| 2021-01-01 | YCEncord The data layer for physical AI · encord.com | still up |
| 2021-08-24 | easyzoom.com | still up |
| 2021-01-01 | YCAbacum The AI-native FP&A platform that helps Finance teams drive business… · abacum.ai | still up |
| 2021-01-11 | thumbnail.ai | unverified |
| 2021-01-01 | YCPibit.ai The fastest path from submission to better decisions. · pibit.ai | still up |
| 2021-07-27 | photoroom.com | still up |
| 2021-01-01 | YCCodingal Leading online after-school for kids & teens to learn AI & coding · codingal.com | still up |
| 2021-09-24 | gocoder.one | still up |
| 2021-01-01 | Building the next generation AI creative studio · moonvalley.com | still up |
| 2021-01-01 | YCFathom The most flexible AI meeting notetaker ever built. · fathom.ai | still up |
| 2021-06-01 | YCRootly AI-native on-call and incident response carefully crafted to help… · rootly.com | still up |
| 2021-06-01 | YCTavus Building the human layer of AI · tavus.io | still up |
| 2021-08-29 | voicera.co | still up |
| 2021-06-01 | YCAnakin One API to get clean data from any website for your AI agents at scale · anakin.io | still up |
| 2021-06-01 | YCConfido AI-enabled financial automation and intelligence for CPG Brands · confidotech.com | still up |
| 2021-01-01 | YCPopl Your AI GTM platform for In-Person Events · popl.co | still up |
| 2021-01-01 | YCMindee AI Document Understanding API · mindee.com | still up |
| 2021-06-01 | YCSwipe Super AI Accountant for SMBs · getswipe.in | still up |
| 2021-01-01 | YCTreinta Software and AI tools for SMBs in the US and Latin America · treinta.co | still up |
| 2021-01-01 | Physical AI for Warehouses and Factories · fluxauto.ai | still up |
| 2021-01-01 | YCLiveFlow The Unified AI-ERP & FP&A Platform · liveflow.com | still up |
| 2021-01-01 | YCSoraban AI tax workflow platform for accounting firms · soraban.com | still up |
| 2021-01-01 | YCTriomics AI Agents for Oncology EHRs · triomics.com | still up |
| 2021-01-01 | AI-driven online tech school for busy professionals · turingcollege.com | still up |
| 2021-01-01 | YCVapi Voice AI for developers. · vapi.ai | still up |
| 2021-06-01 | YCSully.ai Autonomous team of AI agents that runs the entire hospital operations · sully.ai | still up |
| 2021-07-30 | volantai.org | gone |
| 2021-06-01 | YCLago The AI Native Billing Platform · getlago.com | still up |
| 2021-09-28 | exafunction.com | unverified |
| 2021-07-22 | readow.ai | still up |
| 2021-01-01 | YCAXAR AI Multi-agent orchestration platform · axar.ai | gone |
| 2021-01-01 | YCWeekday AI recruiter that runs outbound sourcing campaigns to find top talent · weekday.works | still up |
| 2021-10-03 | researchai.co | unverified |
| 2021-06-01 | Track & Boost Your Brand’s Visibility in AI Search · writesonic.com | still up |
| 2021-09-07 | blog.spiceai.org | still up |
How this compares
Y Combinator reports its own outcomes, including acquisitions. The other two are judged by asking the domain, so they are not measured the same way and are never averaged together.
The register re-probes every domain it holds. Some that answered last month stop answering. We send that list — what went quiet, and what it was — once a month. Nothing else.
How this was made. Show HN entries are every post from 2021 to 2023 with at least five points that linked to its own domain; code hosts and free hosting are excluded, because a repository outlives the effort behind it. Product Hunt entries needed 100 votes — a far higher bar, so they are the promoted top slice rather than a like-for-like sample. Both are judged by asking the domain whether it still answers: gone means it no longer resolves, refuses the connection, serves a parking page, or says plainly that it shut down. An HTTP error is not counted as gone — a server answering 404 is one somebody still pays for, and an audit of 25 gone-calls found two such sites alive with only a moved homepage. Y Combinator entries use the status YC publishes itself, which is why only those can say acquired. Squatted domains — a lapsed name now serving somebody else's site — are not detected, so these figures run slightly low.