You asked about AI-powered Drug Discovery
1,454 people built something like it. 109 are gone.
That is 8% of the ones whose fate we could settle, against 23% across the whole register. 84 were acquired.
| Launched | What it was | Today |
|---|---|---|
| 2024-01-01 | AI Inference Platform for Drug Discovery · tamarind.bio | still up |
| 2019-01-01 | YC1910 Multimodal AI Platform for Modality Agnostic Drug Discovery™ · 1910.ai | still up |
| 2020-06-01 | Combining 3D cell culture & AI to translate drugs to clinical success · knownmed.com | acquired |
| 2023-01-01 | Generative AI for protein design · diffuse.bio | still up |
| 2020-06-01 | We use AI to design antibodies for intractable diseases · nabla.bio | still up |
| 2024-06-01 | Gen AI molecular simulations that reproduce wetlab results · angstrom-ai.com | still up |
| 2023-06-01 | YCNanograb Deliver genes to any cell with AI · nanograb.com | still up |
| 2025-06-01 | YCConvexia The world's first AI-maximalist pharma company · convexia.bio | still up |
| 2026-06-01 | AI-native pharma company · atlasdiscovery.bio | still up |
| 2023-01-01 | AI for drug formulation · lavo.ai | gone |
| 2026-06-01 | YCWonderTx Extrapolative AI to unlock First-in-Class drugs · wondertx.ai | still up |
| 2020-01-01 | Menten AI designs peptide and protein therapeutics using quantum… · menten.ai | still up |
| 2018-06-01 | Synkrino's AI, SATIS is a powerful, unbiased discovery system for… · synkrino.bio | still up |
| 2015-06-01 | We use human data and AI to develop better drugs faster. · vergegenomics.com | still up |
| 2022-01-01 | Unleashing the potential of DNA and RNA based therapies using AI · whitelabgx.com | still up |
| 2019-06-01 | Arpeggio Bio develops drugs targeting transcription factors using AI… · arpeggiobio.com | still up |
| 2025-01-01 | AI drug discovery platform for neurotherapeutics · exintherapeutics.com | still up |
| 2023-01-01 | Developing long-lasting drug formulations 50% faster · persist-ai.com | still up |
| 2026-01-01 | YCOrigin AI and Data for Cancer Therapeutics · origin.bio | still up |
| 2025-09-01 | YCExonic Exonic is an AI-native cell and gene therapeutics company. · exonic.ai | still up |
| 2026-06-01 | AI-native materials discovery powered by unpublished experimental data · 83sciences.ai | still up |
| 2026-01-01 | Multimodal foundation models to predict uncollected patient biology · strandai.com | still up |
| 2023-01-01 | AI Powered Product Discovery · rubberduckylabs.io | gone |
| 2026-01-01 | The first AI-powered uranium discovery company · terranox.ai | still up |
| 2019-06-01 | AI platform accelerating therapies for rare & inflammatory diseases. · gen1e.com | still up |
| 2015-01-01 | AI-powered technology enabler and digital transformer of American… · grubmarket.com | still up |
| 2015-06-01 | YCIronclad AI-powered contract management · ironcladapp.com | still up |
| 2014-01-01 | YCUnbabel AI-powered Language Operations platform · unbabel.com | acquired |
| 2017-06-01 | AI-powered checkout for retail. · standard.ai | still up |
| 2023-01-01 | YCAvoca AI-powered Sales Agent for Service-Based Industries · avoca.ai | still up |
| 2022-01-01 | YCRDash AI Powered Construction Management Software · rdash.io | still up |
| 2019-01-01 | YCGoLinks Intuitive, easy-to-remember short links - powered by AI. · golinks.io | still up |
| 2017-06-01 | AI-Powered Building Management · vergesense.com | still up |
| 2022-06-01 | YCJuicebox AI-powered talent sourcing for recruiters · juicebox.ai | still up |
| 2022-06-01 | YCAiPrise AI-powered Global Compliance Platform · aiprise.com | still up |
| 2021-06-01 | YCVerihubs AI-powered Deepfake Detection · verihubs.com | still up |
| 2021-01-01 | YCHumaans AI-Powered HRIS for high performing teams · humaans.io | still up |
| 2023-06-01 | B2B debt collection powered by AI agents · agentcollect.com | still up |
| 2018-01-01 | YCVeriff AI-powered identity verification solution for fraud prevention. · veriff.com | still up |
| 2017-01-01 | YCSpeak A superhuman, AI-powered language tutor in your pocket · speak.com | still up |
| 2020-01-01 | YCTaiv AI-powered tech that makes business TV smarter, engaging, and… · taiv.tv | still up |
| 2023-01-01 | AI-powered care for seniors with chronic disease · kivohealth.com | still up |
| 2022-01-01 | YCUnlayer AI-powered content creation infrastructure for apps · unlayer.com | still up |
| 2020-06-01 | AI-powered user assistance platform · command.ai | acquired |
| 2019-06-01 | YCBeacons An AI-powered, all-in-one business platform for content creators · beacons.ai | still up |
| 2021-01-01 | AI-powered customer service for startups · cloudhumans.com | still up |
| 2023-01-01 | YCTruewind AI-Powered Accounting · truewind.ai | still up |
| 2022-01-01 | YCCuracel AI-Powered Infrastructure for Insurance & Healthcare · curacel.co | still up |
| 2015-06-01 | ROSS is an AI-powered legal research platform that can read and… · rossintelligence.com | gone |
| 2023-06-01 | YCOutset AI-powered user interviews · outset.ai | still up |
| 2021-01-01 | YCMoichor AI Powered Animal Diagnostics · moichor.com | still up |
| 2021-01-01 | Generative AI powered Shopify for home service professionals · toplinepro.com | still up |
| 2023-06-01 | YCCercli AI powered HR and Recruitment for people teams · cercli.com | still up |
| 2018-06-01 | YCCurebase Modern, AI-powered clinical trial software platform. · curebase.ai | still up |
| 2020-06-01 | Financial data layer for AI-powered finance and accounting · blueonion.ai | still up |
| 2019-01-01 | YCDemodesk AI-powered sales coaching · demodesk.com | still up |
| 2021-01-01 | AI-powered Compliance Platform for PCI 4, CCPA, HIPAA, CIPA, 50+ laws · feroot.com | still up |
| 2022-01-01 | YCFinku AI powered personal finance app for Indonesia · finku.id | still up |
| 2023-01-01 | AI-Powered Super Mentor for Test Prep · superkalam.com | still up |
| 2021-01-01 | YCSpokn AI-powered video platform for Internal Comms and HR teams · getspokn.com | still up |
How this compares
Older launches have had longer to die, so this slope is expected. A year that broke it would mean something is wrong with the checking.
Matched on whole words in the title and description, so a launch can fall into two categories and plenty fall into none.
The register re-probes every domain it holds. Some that answered last month stop answering. We send that list — what went quiet, and what it was — once a month. Nothing else.
How this was made. Show HN entries are every post from 2021 to 2023 with at least five points that linked to its own domain; code hosts and free hosting are excluded, because a repository outlives the effort behind it. Product Hunt entries needed 100 votes — a far higher bar, so they are the promoted top slice rather than a like-for-like sample. Both are judged by asking the domain whether it still answers: gone means it no longer resolves, refuses the connection, serves a parking page, or says plainly that it shut down. An HTTP error is not counted as gone — a server answering 404 is one somebody still pays for, and an audit of 25 gone-calls found two such sites alive with only a moved homepage. Y Combinator entries use the status YC publishes itself, which is why only those can say acquired. Squatted domains — a lapsed name now serving somebody else's site — are not detected, so these figures run slightly low.